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ADAM22 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. De plus, nous expédions ADAM22 Kits (9) et ADAM22 Protéines (8) et beaucoup plus de produits pour cette protéine.
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Mammalian Monoclonal ADAM22 Primary Antibody pour ISt, IHC - ABIN1304515
Zhou, Lee, Jin, Wright, Smith, Anderson: Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. dans Nature medicine 2009
Show all 6 Pubmed References
Mammalian Monoclonal ADAM22 Primary Antibody pour ISt, IHC - ABIN1304516
Ogawa, Oses-Prieto, Kim, Horresh, Peles, Burlingame, Trimmer, Meijer, Rasband: ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Show all 2 Pubmed References
LGI1 (Montrer LGI1 Anticorps) and ADAM22 form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of PSD-95 (Montrer DLG4 Anticorps)
Interaction proteomics revealed the interactors of Caspr2 (Montrer CNTNAP2 Anticorps), including CNTN2 (Montrer CNTN2 Anticorps), KCNAs, members of the ADAM family (ADAM22, ADAM23 (Montrer Adam23 Anticorps) and ADAM11 (Montrer ADAM11 Anticorps)), members of LGI family and MAGUKs (DLGs and MPPs (Montrer MPHOSPH6 Anticorps)).
ADAM22 is an axonal component of the Kv1 (Montrer KCNA5 Anticorps) K+ channel (Montrer KCNC4 Anticorps) complex that recruits membrane-associated guanylate kinase (Montrer GUK1 Anticorps) to juxtaparanodes
ADAM22 is closely involved in the correct functioning of the nervous system.
study identified LGI1 (Montrer LGI1 Anticorps) as a specific binding partner of ADAM22 protein from mouse brain, and demonstrated the specific interaction between LGI1 (Montrer LGI1 Anticorps) and ADAM22
these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE (Montrer LGI1 Anticorps)-causing LGI1 (Montrer LGI1 Anticorps) mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 (Montrer LGI1 Anticorps) with both ADAM22 and ADAM23 (Montrer Adam23 Anticorps) play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy
Disruption of LGI1 (Montrer LGI1 Anticorps)-ADAM22 interaction reduces synaptic AMPA (Montrer GRIA3 Anticorps) receptors in hippocampal neurons.
Data suggest that ADAM22 plays roles in cell differentiation, cell migration, and resistance to endocrine therapy in breast cancer; ADAM22 may serve as biomarker for poor disease-free survival in breast cancer patients. [REVIEW]
findings suggest that SRC-1 (Montrer SRC Anticorps) switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 (Montrer SRC Anticorps) target gene ADAM22 has a critical role
Mutations in disintegrin domain sequence in ADAM22 gene is associted with reduced LGI4 (Montrer LGI4 Anticorps)-binding abilities resulting in epilepsy.
Transgenic leucine-rich glioma-inactivated 4 (Lgi4 (Montrer LGI4 Anticorps)) and transgenic Adam22 proteins are both expressed in Schwann cells as well as in sensory neurons; binding of Lgi4 (Montrer LGI4 Anticorps) to axonal Adam22 is required on axons to drive myelin formation.
role for the 14-3-3zeta (Montrer YWHAZ Anticorps)/ADAM 22 association in the regulation of cell adhesion and related signaling events
demonstrated a functional role for ADAM22/14-3-3 (Montrer YWHAQ Anticorps) in cell adhesion and spreading
ADAM22, a brain-specific (Montrer CALY Anticorps) cell surface protein (Montrer CD28 Anticorps), mediates growth inhibition using an integrin dependent pathway. It is expressed in normal brain but not in high-grade gliomas.
This study indicated ADAM22 gene is probably not a major gene for this epilepsy syndrome.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.
a disintegrin and metalloprotease domain (ADAM) 22
, disintegrin and metalloproteinase domain-containing protein 22
, a disintegrin and metalloprotease domain 22
, a disintegrin and metalloproteinase domain 22
, metalloproteinase-disintegrin ADAM22-3
, metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
, ADAM 22
, metalloprotease-disintegrin MDC11b
, metalloprotease/disintegrin xMDC11.2