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FOXI1 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. De plus, nous expédions FOXI1 Protéines (8) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal FOXI1 Primary Antibody pour ELISA, IHC - ABIN268713
Blomqvist, Vidarsson, Söder, Enerbäck: Epididymal expression of the forkhead transcription factor Foxi1 is required for male fertility. dans The EMBO journal 2006
Show all 2 Pubmed References
Data indicate that foxi1 is expressed in branchial arch ectoderm and endoderm, and morpholino knock-down of foxi1 causes apoptosis of neural crest in the branchial arches, which is rescued by fgf3 (Montrer FGF3 Anticorps).
Foxi1 and Dlx3b/4b regulate the neuronal and sensory lineages of the inner ear.
pax8 (Montrer PAX8 Anticorps) works with related genes pax2a/pax2b to downregulate otic expression of foxi1, a necessary step for further otic development
Data show that the hearsay mutation disrupts foxi1, a forkhead domain-containing gene, expressed in otic precursor cells before placodes become visible, and which appears to be the earliest marker known for the otic anlage.[foxi1]
Foxi1 is necessary for pax8 (Montrer PAX8 Anticorps) expression in the otic placode allowing fgf3 (Montrer FGF3 Anticorps)/8 activation and also for pax8 (Montrer PAX8 Anticorps) expression in the pharyngeal pouchs. Foxi1 is also necessary to maintain fgf3 (Montrer FGF3 Anticorps) expression in the pharyngeal pouchs.
FoxI1 is capable of remodeling chromatin higher-order structure and can stably create site-specific changes in chromatin to either stably create or remove DNase I (Montrer DNASE1 Anticorps) hypersensitive sites.
Foxi1 provide competence for cells to respond to Fgf and form an otic placode
We found no evidence for a significant association between mutations of KCNJ10 (Montrer KCNJ10 Anticorps) and FOXI1 with SLC26A4 (Montrer SLC26A4 Anticorps) in Pendred syndrome/enlarged vestibular aqueducts.
No FOXI1 mutations were present in bilateral deafness patients with inner ear malformation.
SLC26A4 (Montrer SLC26A4 Anticorps), FOXI1 and KCNJ10 (Montrer KCNJ10 Anticorps) are not major determinants in unilateral deafness and enlarged vestibular aqueduct
C/EBP alpha (Montrer CEBPA Anticorps) and HNF-3 gamma (Montrer FOXA3 Anticorps) cooperatively regulate CYP3A4 (Montrer CYP3A4 Anticorps) expression in hepatic cells by a mechanism that probably involves chromatin remodeling.
Data suggestthat Foxi1 is necessary for expression of at least four subunits in three different epithelia and most likely is a major determinant for proper assembly of a functional vacuolar H(+)-ATPase (Montrer ATP6V1B2 Anticorps) complex at these locations.
mutations in FOXI1 could prove to cause a Pendred syndrome-like human deafness
examined the expression patterns of the Foxi class genes from embryonic day 6.5 to 10.5; Foxi1 expression is first detected in the endolymphatic duct in the otic vesicle at E10.5
The AE4 (Montrer SLC4A9 Anticorps) promoter is identified as a direct target of Foxi1.
Spermatozoa from Foxi1 null males fail to reach the female genital tract in sufficient number to allow fertilization.
Foxa1 (Montrer FOXA1 Anticorps) and Foxi1 are required for later stage sweat gland development.
Foxi2 thus acts as a link between the oocyte and the early pathway to ectoderm
Xema is both necessary and sufficient for the inhibition of ectopic mesendoderm in the cells of the presumptive ectoderm
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene.
forkhead box protein I1
, Xenopus ectodermally-expressed mesendoderm antagonist
, ectodermally-expressed mesendoderm antagon
, ectodermally-expressed mesendoderm antagonist
, forkhead box protein I1-ema
, forkhead box I1
, forkhead box protein I1-like
, HNF-3/fork-head homolog 3
, HNF-3/fork-head homolog-3
, forkhead-like 10
, forkhead-related activator 6
, forkhead-related protein FKHL10
, forkhead-related transcription factor 6
, hepatocyte nuclear factor 3 forkhead homolog 3
, HNF-3/forkhead homolog 3
, forkhead homolog 10
, no soul