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anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) Anticorps

The protein encoded by NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. De plus, nous expédions Neutrophil Cytosolic Factor 4, 40kDa Protéines (9) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
NCF4 17972 P97369
NCF4 500904  
NCF4 4689 Q15080
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Top anti-Neutrophil Cytosolic Factor 4, 40kDa Anticorps sur anticorps-enligne.fr

Showing 10 out of 111 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-NCF4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Chèvre Inconjugué IHC, ELISA, WB ABIN190755 (0.5µg/ml) staining of Daudi cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 3 to 4 Days
341,55 €
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis of NCF4 antibody (C-term) (ABIN391905) in K562 cell line lysates (35 µg/lane). NCF4 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lymphoma reacted with NCF4 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Chien Chèvre Inconjugué EIA, IHC (p), WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Souris Inconjugué ELISA Detection limit for recombinant GST tagged NCF4 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Connectez-vous pour afficher 12 to 16 Days
454,76 €
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-NCF4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Muscle WB Suggested Anti-NCF4  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Human Muscle 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué IHC (p) 0.1 mg Connectez-vous pour afficher 8 to 10 Days
385,00 €
Détails
Humain Lapin Inconjugué IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human ovary, using p40 phox (Phospho-Thr154) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails
Humain Lapin Inconjugué IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human ovary tissue, using p40 phox (Ab-154) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails

NCF4 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Neutrophil Cytosolic Factor 4, 40kDa Anticorps mieux référencés

  1. Human Monoclonal NCF4 Primary Antibody pour ELISA - ABIN393677 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. dans Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN393677

  2. Human Polyclonal NCF4 Primary Antibody pour FACS, IHC (p) - ABIN391905 : Glas, Seiderer, Pasciuto, Tillack, Diegelmann, Pfennig, Konrad, Schmechel, Wetzke, Török, Stallhofer, Jürgens, Griga, Klein, Epplen, Schiemann, Mussack, Lohse, Göke, Ochsenkühn, Folwaczny, Müller-Myhsok, Brand: rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population. dans The American journal of gastroenterology 2009 (PubMed)
    Show all 2 references for ABIN391905

  3. Cow (Bovine) Polyclonal NCF4 Primary Antibody pour WB - ABIN2782428 : Chen, He, Minshall, Dinauer, Ye: Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production. dans The Journal of biological chemistry 2007 (PubMed)

  4. Dog (Canine) Polyclonal NCF4 Primary Antibody pour EIA, IHC (p) - ABIN374770 : Rioux, Xavier, Taylor, Silverberg, Goyette, Huett, Green, Kuballa, Barmada, Datta, Shugart, Griffiths, Targan, Ippoliti, Bernard, Mei, Nicolae, Regueiro, Schumm, Steinhart, Rotter, Duerr, Cho, Daly et al.: Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. ... dans Nature genetics 2007 (PubMed)

Plus d’anticorps contre Neutrophil Cytosolic Factor 4, 40kDa partenaires d’interaction

Mouse (Murine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. p40phox deficiency leads to upregulation of chemokine receptor 1 (Montrer CMKLR1 Anticorps) and downregulation of fucosyltransferases and sialyltransferases involved in glycan modifications during experimental intestinal inflammation.

  2. cooperation of p40(phox) with p47(phox) for Nox2 (Montrer CYBB Anticorps)-based NADPH oxidase (Montrer NOX1 Anticorps) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  3. The defect in Reactive Oxygen Species production and killing of s aureus by p40(phox-/-) neutrophils defines p40(phox) as an essential component in bacterial killing.

  4. p40 (Montrer LANCL1 Anticorps)(phoxR58A/R58A) embryos do not develop normally but p40 (Montrer LANCL1 Anticorps)(phoxR58A/-) mice are viable and neutrophils from these animals exhibit significantly reduced oxidase responses compared to those from their p40(phox+/-) siblings.

  5. Class III PI3K Vps34 (Montrer PIK3C3 Anticorps) is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18 (Montrer ITGB2 Anticorps)-dependent activation oxidase activation in response to S aureus and E coli

  6. p40(phox) is prephosphorylated in resting endothelial cells and can compensate p47(phox) in keeping basal ROS (Montrer ROS1 Anticorps) production.

Human Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. NCF4 polymorphism was associated with Crohn's disease, but not ulcerative colitis in Caucasian--{REVIEW}

  2. NCF4 may induce ex- pression of NADPH oxidase (Montrer NOX1 Anticorps) enzymes, such as p67phox (Montrer NCF2 Anticorps), p47phox (Montrer NCF1 Anticorps), p22phox (Montrer CYBA Anticorps) and NOX2 (Montrer CYBB Anticorps), which lead to increased ROS (Montrer ROS1 Anticorps) levels.

  3. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer.

  4. The contribution of the functionally relevant NADPH (Montrer NQO1 Anticorps) polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity.

  5. Constitutive and inducible intracellular production of reactive oxygen species (ROS (Montrer ROS1 Anticorps)) is higher in B cells expressing functional p40phox, supporting a direct role for p40phox in regulating B cell intracellular ROS (Montrer ROS1 Anticorps) generation.

  6. Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults.

  7. Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease.

  8. cooperation of p40(phox) with p47(phox) for Nox2 (Montrer CYBB Anticorps)-based NADPH oxidase (Montrer NOX1 Anticorps) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  9. Results demonstrate that PBEF (Montrer NAMPT Anticorps) can prime for PMN (Montrer TBCE Anticorps) respiratory burst activity by promoting p40 (Montrer IL9 Anticorps) and p47 (Montrer ING1 Anticorps) translocation to the membrane.

  10. cytosolic localisation depends on direct interaction with F-actin

Cow (Bovine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. Study proposes that NCF4 splice variants generated by functional SNP are important risk factors for mastitis susceptibility in dairy cows.

Neutrophil Cytosolic Factor 4, 40kDa (NCF4) profil antigène

Profil protéine

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with NCF4

  • p40phox protein (p40phox) anticorps
  • neutrophil cytosolic factor 4 (LOC100136241) anticorps
  • neutrophil cytosolic factor 4 (Ncf4) anticorps
  • neutrophil cytosolic factor 4, 40kDa (NCF4) anticorps
  • AI451400 anticorps
  • NCF anticorps
  • P40PHOX anticorps
  • SH3PXD4 anticorps

Protein level used designations for NCF4

p40phox protein , neutrophil cytosolic factor 4 , NADPH oxidase cytosolic protein p40phox , NCF-4 , neutrophil NADPH oxidase factor 4 , neutrophil cytosol factor 4 , p40-phox , SH3 and PX domain-containing protein 4

GENE ID SPECIES
445891 Takifugu rubripes
100136241 Oncorhynchus mykiss
17972 Mus musculus
500904 Rattus norvegicus
4689 Homo sapiens
481277 Canis lupus familiaris
507859 Bos taurus
100009359 Oryctolagus cuniculus
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