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anti-SH2 Domain Containing 1A (SH2D1A) Anticorps

SH2D1A encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. De plus, nous expédions SH2 Domain Containing 1A Protéines (20) et SH2 Domain Containing 1A Kits (1) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SH2D1A 4068 O60880
SH2D1A 501502 B2RZ59
SH2D1A 20400 O88890
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Top anti-SH2 Domain Containing 1A Anticorps sur anticorps-enligne.fr

Showing 10 out of 121 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Chèvre Inconjugué ELISA, WB ABIN185426 staining (0.3µg/ml) of Human Thymus lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Chèvre Inconjugué WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Chèvre Inconjugué WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Lapin Inconjugué IP, WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué WB SH2D1A Antibody (C-term) (ABIN1881802) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the SH2D1A antibody detected the SH2D1A protein (arrow). 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Chèvre Inconjugué ELISA, WB ABIN251451 (0.2?g/ml) staining of Human Lymph Node lysate (35?g protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Western Blot: SH2D1A Antibody [ABIN2514513] - Analysis of SH2D1A using ABIN2514513 at 0.2 ug/ml in Human Lymph Node lysate (35ug protein in RIPA buffer). 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-SH2D1A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate WB Suggested Anti-SH2D1A  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Jurkat cell lysate  SH2D1A is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Souris Inconjugué ELISA, WB SH2D1A monoclonal antibody (M01), clone 1C9 Western Blot analysis of SH2D1A expression in Jurkat . Western Blot analysis of SH2D1A expression in transfected 293T cell line by SH2D1A monoclonal antibody (M01), clone 1C9.Lane 1: SH2D1A transfected lysate(14.2 KDa).Lane 2: Non-transfected lysate. 100 μg Connectez-vous pour afficher 8 to 9 Days
369,60 €
Détails
Humain Souris Inconjugué WB SH2D1A monoclonal antibody (M01), clone 1C9 Western Blot analysis of SH2D1A expression in Jurkat. 0.1 mg Connectez-vous pour afficher 12 to 16 Days
454,76 €
Détails
Boeuf (Vache) Lapin Inconjugué WB Western blot analysis of SH2D1A expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 7 to 8 Days
464,29 €
Détails

SH2D1A Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-SH2 Domain Containing 1A Anticorps mieux référencés

  1. Human Monoclonal SH2D1A Primary Antibody pour ELISA, WB - ABIN561703 : Ma, Suryani, Avery, Chan, Nanan, Santner-Nanan, Deenick, Tangye: Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. dans Immunology and cell biology 2009 (PubMed)
    Show all 5 references for ABIN561703

  2. Human Polyclonal SH2D1A Primary Antibody pour WB - ABIN1881802 : Snow, Marsh, Krummey, Roehrs, Young, Zhang, van Hoff, Dhar, Nichols, Filipovich, Su, Bleesing, Lenardo: Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. dans The Journal of clinical investigation 2009 (PubMed)
    Show all 5 references for ABIN1881802

  3. Human Polyclonal SH2D1A Primary Antibody pour WB - ABIN374582 : Mikhalap, Shlapatska, Yurchenko, Yurchenko, Berdova, Nichols, Clark, Sidorenko: The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. dans Blood 2004 (PubMed)

  4. Human Polyclonal SH2D1A Primary Antibody pour WB - ABIN374629 : Romero, Benítez, March, Vilella, Miralpeix, Engel: Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). dans Tissue antigens 2004 (PubMed)

  5. Human Polyclonal SH2D1A Primary Antibody pour IP, WB - ABIN265020 : Sayos, Wu, Morra, Wang, Zhang, Allen, van Schaik, Notarangelo, Geha, Roncarolo, Oettgen, De Vries, Aversa, Terhorst: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. dans Nature 1998 (PubMed)

Plus d’anticorps contre SH2 Domain Containing 1A partenaires d’interaction

Human SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. High LAT1 (Montrer LAT Anticorps) expression correlated with significantly shorter prostate specific antigen (Montrer KLK3 Anticorps) recurrence-free survival in patients receiving androgen deprivation therapy

  2. We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (Montrer SLAMF1 Anticorps))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM (Montrer ZMYM2 Anticorps)) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.

  3. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  4. The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation

  5. Study of SAP (Montrer APCS Anticorps) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (Montrer CD244 Anticorps) functional assay allows identification of all cases

  6. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (Montrer APCS Anticorps) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (Montrer SLAMF1 Anticorps) peptide.

  7. Signaling lymphocytic activation molecule (SLAM)/SLAM (Montrer SLAMF1 Anticorps)-associated protein pathway regulates human B-cell tolerance.

  8. In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (Montrer APCS Anticorps) is nonfunctional, not only abolishing the activating function of 2B4 (Montrer CD244 Anticorps), but rendering this receptor inhibitory.

  9. our data reveal how SAP (Montrer APCS Anticorps) nucleates a previously unknown signaling complex involving NTB-A (Montrer SLAMF6 Anticorps) and LCK (Montrer LCK Anticorps) to potentiate restimulation-induced cell death of activated human T cells.

  10. SAP (Montrer APCS Anticorps) is a new actor downstream of PECAM-1 (Montrer PECAM1 Anticorps) and its binding regulates PECAM-1 (Montrer PECAM1 Anticorps) mediated cell adhesion.

Mouse (Murine) SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. SAP (Montrer APCS Anticorps) is an essential molecule for autoimmune antibody production.

  2. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  3. SLAM (Montrer SLAMF1 Anticorps)-SAP (Montrer APCS Anticorps) signaling promotes differentiation of IL-17 (Montrer IL17A Anticorps)-producing T cells and progression of experimental autoimmune encephalomyelitis.

  4. these data suggest that SAP (Montrer APCS Anticorps) is critical for regulating type II NKT (Montrer CTSL1 Anticorps) cell responses.

  5. functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability

  6. Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (Montrer APCS Anticorps)-/- mice and in Rag-/- mice into which B cells derived from SAP (Montrer APCS Anticorps)-/- mice together with wt CD4 (Montrer CD4 Anticorps)+ T cells had been transferred.

  7. SAP (Montrer APCS Anticorps) plays an essential role in CIA (Montrer NCOA5 Anticorps) because of Fyn (Montrer FYN Anticorps)-independent and Fyn (Montrer FYN Anticorps)-dependent effects on TFH cells and, possibly, other T cell types.

  8. SAP (Montrer APCS Anticorps) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.

  9. Loss of SAP (Montrer APCS Anticorps) expression is associated with invariant NKT (Montrer CTSL1 Anticorps) cell cytotoxicity and defective lytic synapse formation.

  10. SAP (Montrer APCS Anticorps) is required for the development of innate phenotype in H2-M3--restricted Cd8 (Montrer CD8A Anticorps)(+) T cells.

SH2 Domain Containing 1A (SH2D1A) profil antigène

Profil protéine

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SH2D1A

  • SH2 domain containing 1A (SH2D1A) anticorps
  • SH2 domain containing 1A (Sh2d1a) anticorps
  • SH2 domain protein 1A (Sh2d1a) anticorps
  • SH21A (LOC780420) anticorps
  • DSHP anticorps
  • EBVS anticorps
  • Gm686 anticorps
  • IMD5 anticorps
  • LYP anticorps
  • MTCP1 anticorps
  • RGD1562408 anticorps
  • SAP anticorps
  • SAP/SH2D1A anticorps
  • SH2D1A anticorps
  • XLP anticorps
  • XLPD anticorps

Protein level used designations for SH2D1A

Duncan disease SH2-protein , SH2 domain-containing protein 1A , SLAM associated protein/SH2 domain protein 1A , SLAM-associated protein , T cell signal transduction molecule SAP , T-cell signal transduction molecule SAP , signaling lymphocyte activation molecule-associated protein , signaling lymphocytic activation molecule-associated protein , SH2 domain protein 1A , SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) , Signaling lymphocytic activation molecule-associated protein , Duncan disease homolog

GENE ID SPECIES
4068 Homo sapiens
501502 Rattus norvegicus
613356 Bos taurus
574156 Macaca mulatta
20400 Mus musculus
780420 Sus scrofa
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