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Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity).. De plus, nous expédions SOHLH2 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal SOHLH2 Primary Antibody pour IF (p), IHC (p) - ABIN1713906
Ding, Wang, Wu, Zhao, Zhang, Li: Protection of Murine Spermatogenesis Against Ionizing Radiation-Induced Testicular Injury by a Green Tea Polyphenol. dans Biology of reproduction 2014
Results identified MMP9 (Montrer MMP9 Anticorps) as a novel target for transcriptional inactivation by Sohlh2 and demonstrated that the Sohlh2 downregulation of MMP9 (Montrer MMP9 Anticorps) is critical for inhibiting human ovarian cancer cell invasion.
The polymorphisms rs1328626 and rs6563386 of the SOHLH2 gene would be the genetic risk factors for nonobstructive azoospermia in the Chinese population. The SNP rs1328641 might influence testes development in the NOA (Montrer DLAT Anticorps) patients.
Low Sohlh2 expression is associated with ovarian cancer.
Our identification of novel variants in the SOHLH2 gene, in women with POF (Montrer POF1B Anticorps) of both Chinese and Serbian origin, strongly suggests an important role for SOHLH2 in human POF (Montrer POF1B Anticorps) etiology.
Sohlh1 (Montrer SOHLH1 Anticorps) and Sohlh2 are essential regulators of oocyte differentiation but do not affect meiosis I.
SOHLH2 is critical for the formation of synaptonemal complexes.
Sohlh2 may inhibit oocyte apoptosis via c-kit (Montrer KIT Anticorps)/PI3K/Akt (Montrer AKT1 Anticorps)/Foxo3a (Montrer FOXO3 Anticorps) signalling pathway
SOHLH1 (Montrer SOHLH1 Anticorps) and SOHLH2 were able to directly and cooperatively repress STRA8 (Montrer STRA8 Anticorps) expression in cell lines in vitro through binding to its promoter.
Our findings suggest that an SOHLH2/SOHLH1 (Montrer SOHLH1 Anticorps)/SP1 (Montrer SP1 Anticorps) ternary complex autonomously and cooperatively regulates Sohlh1 (Montrer SOHLH1 Anticorps) gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis.
Effects of BMP4 (Montrer BMP4 Anticorps) on mouse primordial follicle growth were assayed by follicle count and TUNEL labeling. The expression of phospho-SMAD1 (Montrer SMAD1 Anticorps)/5/8, Sohlh2, and c-kit (Montrer KIT Anticorps) were measured by immunohistochemistry, RT-PCR, and Western blotting.
SOHLH1 (Montrer SOHLH1 Anticorps) and SOHLH2 directly stimulate Kit transcription in postnatal spermatogonia, thus activating the signaling involved in spermatogonia differentiation and spermatogenetic progression.
Data suggest that a dynamic DNA CpG methylation in Sohlh2 and Figlalpha promoters, but not in the intron and exon sequences, is linked to regulation of gene expression, even though CpG islands are also present in their introns or exons.
SOHLH1 (Montrer SOHLH1 Anticorps) and SOHLH2 suppress genes involved in spermatogonial stem cell maintenance, and induce genes important for spermatogonial differentiation.
The expression pattern of SOHLH2 suggests that it may be a critical regulator of early germ cell development.
Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity).
spermatogenesis and oogenesis specific basic helix-loop-helix 2
, spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2-like
, spermatogenesis associated 28
, spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2