SERPINB9 anticorps

N° du produit ABIN1109125

Détail du produit anti-SERPINB9 anticorps

Antigène: SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SERPINB9 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificité: The antibody recognizes Mouse Spi-6, also known as Serpin B9, a cytoplasmic serine protease inhibitor of ~42 kDa. It shows no crossreactivity with Mouse proteins related to Spi-6.

Réactivité croisée (Details): Species reactivity (tested):Mouse.

Purification: Protein A Chromatography

Immunogène: Recombinant GST-Spi-6

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8 °C.

Détails sur SERPINB9

Antigène: SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))

Autre désignation: Spi-6 (SERPINB9 Produits)

Synonymes: anticorps SERPINB9, anticorps BB283241, anticorps CAP-3, anticorps CAP3, anticorps PI-9, anticorps PI9, anticorps Spi6, anticorps ovalbumin, anticorps serpin family B member 9, anticorps serpin peptidase inhibitor, clade B (ovalbumin), member 9, anticorps serine (or cysteine) peptidase inhibitor, clade B, member 9, anticorps Serpinb9, anticorps SERPINB9

Sujet: Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer.Synonyms: Cytoplasmic antiproteinase 3, PI-9, serpin B9

ID gène: 20723

NCBI Accession: NP_033282

UniProt: O08797