MORC3 anticorps

N° du produit ABIN1449250

Détail du produit anti-MORC3 anticorps

Antigène: MORC3 (MORC Family CW-Type Zinc Finger 3 (MORC3))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MORC3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects MORC3.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Protein A agarose

Immunogène: Recombinant human MORC3

Clone: 17A9

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur MORC3

Antigène: MORC3 (MORC Family CW-Type Zinc Finger 3 (MORC3))

Autre désignation: MORC3 (MORC3 Produits)

Synonymes: anticorps NXP2, anticorps ZCW5, anticorps ZCWCC3, anticorps 1110051N18Rik, anticorps AI452146, anticorps BF318192, anticorps D16Jhu32e, anticorps Zcwcc3, anticorps sb:cb561, anticorps sb:cb69, anticorps zgc:101052, anticorps fb73c08, anticorps wu:fb73c08, anticorps zgc:162471, anticorps morc3, anticorps MORC family CW-type zinc finger 3, anticorps microrchidia 3, anticorps MORC family CW-type zinc finger 3b, anticorps MORC family CW-type zinc finger 3a, anticorps MORC family CW-type zinc finger 3 S homeolog, anticorps MORC3, anticorps Morc3, anticorps morc3b, anticorps morc3a, anticorps morc3.S

Sujet: MORC3 { m icr orc hidia (MORC) family CW-type zinc finger 3 , KIAA0136, ZCWCC3 and NXP-2}, is a member of the MORC protein family characterized by the conser ved domains consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the N-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the C-terminus. There are four MORC family proteins (MORC1, MORC2, MORC3, and MORC4) in human and five (Morc1, Morc2a, Morc2b, Morc3, and Morc4) in mice. MORC1 is expressed specifically in male germ cells, whereas MORC2 and MORC3 in human are ubiquitously expressed. The autosomal recessive mutation of Morc1 in mice causes the arrest of spermatogenesis early in prophase I of meiosis. Takahashi et al . reported that MORC3 is involved in p53 activation and localization of conditionally localized p53 and constitutively localized Sp100 to promyelocytic leukemia (PML)-nuclear bodies (NBs) through its GHL-ATPase activity. MORC3 is localized in PML-nuclear bodies and entire nucleoplasm except for nucleoli.Synonyms: KIAA0136, MORC family CW-type zinc finger protein 3, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3

ID gène: 23515

NCBI Accession: NP_056173

UniProt: Q14149

Pathways: Maintenance of Protein Location