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FRAT1 anticorps (Frequently Rearranged in Advanced T-Cell Lymphomas) (HRP)

Détail du produit anti-FRAT1 anticorps No. ABIN1712053, Fournisseur: Connectez-vous pour afficher
Antigène
  • FRAT1
  • frat1
  • AW060382
  • gbp
  • frequently rearranged in advanced T-cell lymphomas
  • GSK-3 binding protein FRAT1
  • frequently rearranged in advanced T cell lymphomas
  • FRAT1
  • frat1
  • Frat1
Reactivité
Humain, Souris, Rat (Rattus)
32
15
14
Hôte
Lapin
31
1
Clonalité
Polyclonal
Conjugué
Cet anticorp FRAT1 est conjugé à/à la HRP
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
18
13
11
6
5
2
2
2
Options
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Immunogène KLH conjugated synthetic peptide derived from human FRAT1
Isotype IgG
Purification Purified by Protein A.
Autre désignation Frat1 (FRAT1 Antibody Extrait)
Sujet

FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.


Synonyms: FRAT 1, frequently rearranged in advanced T cell lymphomas, Frequently rearranged in advanced T-cell lymphomas, GSK 3 binding protein FRAT1, proto oncogene FRAT1, FRAT1_HUMAN.
ID gène 10023
Domaine de recherche Stem Cells, Wnt, Transcription Factors, Adaptive Immunity
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months