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HUWE1 anticorps (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase) (HRP)

Détail du produit anti-HUWE1 anticorps No. ABIN1712174, Fournisseur: Connectez-vous pour afficher
Antigène
  • 5430439H10Rik
  • AU041296
  • Arf-bp1
  • C430014N20Rik
  • C80292
  • Gm1718
  • Ib772
  • LASU1
  • Mule
  • Ureb1
  • ARF-BP1
  • HECTH9
  • HSPC272
  • MULE
  • URE-B1
  • UREB1
  • HECT, UBA and WWE domain containing 1
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
  • Huwe1
  • HUWE1
Reactivité
Humain, Souris, Rat (Rattus)
66
47
28
2
2
2
2
1
1
1
1
1
1
Hôte
Lapin
51
13
2
Clonalité
Polyclonal
Conjugué
Cet anticorp HUWE1 est conjugé à/à la HRP
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
36
25
22
21
21
18
13
3
3
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human ARF6
Isotype IgG
Purification Purified by Protein A.
Autre désignation Arfbp1 (HUWE1 Antibody Extrait)
Sujet

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.


Synonyms: ARF binding protein 1, ARF BP1, ARF-binding protein 1, ARF-BP1, BJ-HCC-24 tumor antigen, E3 ubiquitin protein ligase HUWE1, E3 ubiquitin-protein ligase HUWE1, HECT, HECT domain protein LASU1, HECT UBA and WWE domain containing protein 1, HectH9, Homologous to E6AP carboxyl terminus homologous protein 9, HUWE, Huwe1, HUWE1_HUMAN, Ib772, KIAA0312, KIAA1578, Large structure of UREB1, LASU1, Mcl 1 ubiquitin ligase E3, Mcl-1 ubiquitin ligase E3, MULE, UBA and WWE domain-containing protein 1, Upstream regulatory element-binding protein 1, URE B1, URE-B1, URE-binding protein 1, UREB 1, UREB1.
ID gène 382
Domaine de recherche Proteolysis / Ubiquitin
Indications d'application IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months