This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008].
Synonyms: Cross-immune reaction antigen 1, dJ341E18.2, DKFZp434C0118, F-box only protein 9, Fbp24, FBX9, FBX9_HUMAN, Fbxo9, KIAA0936, NY REN 57, OTTHUMP00000016628, OTTHUMP00000016629, OTTHUMP00000214588, Renal carcinoma antigen NY-REN-57, VCIA1.