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GHRHR anticorps (Growth Hormone Releasing Hormone Receptor) (HRP)

Détail du produit anti-GHRHR anticorps No. ABIN1712319, Fournisseur: Connectez-vous pour afficher
Antigène
  • GHRFR
  • GRFR
  • IGHD1B
  • Ghrfr
  • lit
  • little
  • GHRHREC
  • GHRH-R
  • growth hormone releasing hormone receptor
  • GHRHR
  • Ghrhr
Alternatives
anti-Humain GHRHR anticorps pour Immunohistochemistry (Paraffin-embedded Sections)
Reactivité
Humain, Souris, Rat (Rattus)
82
50
49
7
6
5
5
5
4
4
4
1
Hôte
Lapin
82
Clonalité
Polyclonal
Conjugué
Cet anticorp GHRHR est conjugé à/à la HRP
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
37
26
25
13
11
7
2
2
1
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human GHRHR
Isotype IgG
Purification Purified by Protein A.
Autre désignation GHRHR (GHRHR Antibody Extrait)
Sujet

GHRH-R is a seven transmembrane domain protein that localizes to the somatotroph of the pituitary. GHRH-R plays an important role in growth and acts as a high-affinity receptor for GHRH. Binding of GHRH leads to the coupling of GHRH-R to G-protein which stimulates increased adenylyl cyclase activity and the accumulation of cAMP leading to the synthesis and release of growth hormone and somatotroph proliferation. In addition, this signalling pathway may have direct action in fetal/placental development, reproduction and immune function. GHRH and GHRH-R may also play a role in the regulation of non-rapid eye movement sleep (NREMS). The expression of GHRH-R is dependent on the presence of the POU domain factor Pit-1. Mutations in the gene encoding this protein can result in isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, and anterior pituitary hypoplasia (APH).


Synonyms: GHRFR, GHRH R, GHRH receptor, Ghrhr, GHRHR_HUMAN, GHRHRpsv, GRF R, GRF receptor, GRFR, Growth hormone releasing factor receptor, Growth hormone releasing hormone receptor, Growth hormone-releasing factor receptor, Growth hormone-releasing hormone receptor.
ID gène 2692
Domaine de recherche Neurology
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Hormone Transport, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months