The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2012].
Synonyms: GNRH, Gonadoliberin-1, Progonadoliberin-1, GON1_HUMAN, Progonadoliberin I, Gonadoliberin I, Gonadorelin, Gonadotropin-releasing hormone I, Luliberin I, Luteinizing hormone-releasing hormone I, LH-RH I, progonadoliberin-1 isoform 2 preproprotein, progonadoliberin-1 isoform 1 precursor, GNRH1, GRH, LHRH.