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Notchless Homolog 1 (Drosophila) (NLE1) anticorps (HRP)

Détails pour le produit réf. ABIN1712561, Fournisseur: Connectez-vous pour afficher
Antigène
  • Nle
  • AL022765
  • BC018399
  • l11Jus1
  • l11Jus4
  • RGD1308301
  • notchless homolog 1 (Drosophila)
  • NLE1
  • Nle1
Reactivité
Humain, Souris, Rat (Rattus)
48
24
22
4
4
3
3
3
3
2
1
1
1
1
1
Hôte
Lapin
48
Clonalité
Polyclonal
Conjugué
HRP
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
34
19
13
3
2
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human NLE1
Isotype IgG
Purification Purified by Protein A.
Autre désignation Nle1
Sujet

The Notch signaling pathway is an evolutionary conserved system that is involved in intracellular communication. Notch receptors play an important role in development and cell-fate decisions. Notchless is a loss-of-function mutant allele that encodes for protein NLE1 (notchless homolog 1). NLE1 is a 485 amino acid WD40-repeat protein that binds to the cytoplasmic domain of Notch, regulating its signaling activity in Drosophila melanogaster and in mice. Deletion of the NLE1 gene in mice during the early stages of development results in embryonic death, while gene deletion in the late stages of development leads to activation of a caspase-3-dependent apoptotic pathway. In plants, NLE1 is crucial for normal cellular growth and development. Under-expression during shoot proliferation causes pleiotropic defects such as delayed flowering and abnormal organ maturation. It may also play a role in 60S ribosomal subunit biogenesis in yeast. NLE1 contains eight WD40 domains and produces one isoform due to alternative splicing.


Synonyms: FLJ10458, NLE 1, Nle, Notchless gene homolog, Notchless homolog 1 Drosophila, Notchless homolog 1, Notchless protein homolog 1, NLE1_HUMAN.
ID gène 54475
Domaine de recherche Stem Cells
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months