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CRYAB anticorps (Crystallin, alpha B) (pSer19) (HRP)

Détail du produit anti-CRYAB anticorps No. ABIN1712575, Fournisseur: Connectez-vous pour afficher
Antigène
  • CRYAB
  • CMD1II
  • CRYA2
  • CTPP2
  • CTRCT16
  • HSPB5
  • MFM2
  • Crya-2
  • Crya2
  • HspB5
  • AACRYA
  • crystallin, alpha B
  • hypothetical protein
  • CRYAB
  • alpha-B-crystallin
  • Cryab
Épitope
pSer19
41
39
34
25
24
23
22
15
12
12
10
9
6
6
5
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
462
242
226
143
31
28
8
7
7
6
5
4
4
1
Hôte
Lapin
256
194
16
1
Clonalité
Polyclonal
Conjugué
Cet anticorp CRYAB est conjugé à/à la HRP
21
20
18
10
10
9
9
9
6
6
6
6
6
6
6
6
6
5
5
5
5
5
5
5
5
5
5
5
5
5
4
4
3
3
2
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
363
190
135
126
112
109
78
27
19
5
3
2
1
1
Options
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Immunogène KLH conjugated synthetic phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser19
Isotype IgG
Purification Purified by Protein A.
Autre désignation alpha B Crystallin (CRYAB Antibody Extrait)
Sujet

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].


Synonyms: alpha B Crystallin phospho S19, alpha B Crystallin phospho Ser19, p-alpha B Crystallin S19, p-alpha B Crystallin Ser19, AACRYA, Alpha B crystallin, Alpha crystallin B chain, Alpha crystallin B chain, AlphaB crystallin, AlphaB-crystallin, Alpha-crystallin B chain, CRYA2, CRYAB, CRYAB_HUMAN, Crystallin alpha B, Crystallin alpha polypeptide 2, CTPP 2, CTPP2, Heat shock 20 kD like protein, Heat shock protein beta 5, Heat shock protein beta-5, HSPB5, NY REN 27 antigen, Renal carcinoma antigen NY REN 27, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component.
ID gène 1410
Domaine de recherche Cancer, Tyrosine Kinases
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months