Hephaestin anticorps (HEPH) (HRP)

Details for Product anti-HEPH Antibody No. ABIN1712603, Fournisseur: Connectez-vous pour afficher
Antigène
  • HEPH
  • C130006F04Rik
  • Cpl
  • mKIAA0698
  • sla
  • CPL
  • hephaestin
  • HEPH
  • heph
  • Heph
Reactivité
Humain, Rat (Rattus)
43
27
12
2
1
1
1
1
1
1
Hôte
Lapin
35
12
Clonalité
Polyclonal
Conjugué
Cet anticorp Hephaestin est conjugé à/à la HRP
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
30
24
13
10
3
1
1
1
1
Options
Fournisseur
Connectez-vous pour afficher
Supplier Product No.
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Immunogène KLH conjugated synthetic peptide derived from human Hephaestin
Isotype IgG
Purification Purified by Protein A.
Autre désignation Hephaestin (HEPH Antibody Extrait)
Sujet

Hephaestin is a single-pass type I membrane protein that belongs to the multicopper oxidase family of proteins. Hephaestin, a copper-dependant ferroxidase protein, is crucial for iron exiting intestinal enterocytes into the circulation. It mediates the movement of iron across the basolateral membrane in conjunction with ferroportin 1. This is an important link between iron and copper metabolism in mammalian systems, as copper deficiency leads to reduced hephaestin and reduced iron absorption resulting in anemia. Hephaestin can bind six copper ions per monomer and is regulated by the homeobox transcription factor CDX2. Increased levels of iron leads to an increase in CDX2 expression and thus Hephaestin. Hephaestin is primarily detected in the intestine, but is also expressed in colon, breast, bone trabecural cells and fibroblasts.

Subcellular location: Extracellular

Synonyms: CPL, HEPH, HEPH_HUMAN, Hephaestin.

ID gène 9843
Domaine de recherche Signaling, Metabolism
Pathways Transition Metal Ion Homeostasis
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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