PTGES3 anticorps

N° du produit ABIN263974

Détail du produit anti-PTGES3 anticorps

Antigène: PTGES3 (Prostaglandin E Synthase 3 (Cytosolic) (PTGES3))

Reactivité: Humain, Souris, Cobaye, Lapin, Poulet, Saccharomyces cerevisiae

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PTGES3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Specificité: This antibody detects ~23 kDa p23.

Attributs du produit: Synonyms: Prostaglandin E synthase 3, cPGES, P23, Cytosolic prostaglandin E2 synthase,Telomerase-binding protein p23, Hsp90 co-chaperone, Progesterone receptor complex p23

Purification: Protein G Affinity Chromatography

Immunogène: Recombinant Human full length p23 protein

Clone: JJ6

Isotype: IgG1

Information d'application

Indications d'application: Western blot (1: 2000). Immunprecipitation. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS in 50 % Glycerol, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur PTGES3

Antigène: PTGES3 (Prostaglandin E Synthase 3 (Cytosolic) (PTGES3))

Autre désignation: PTGES3 / TEBP (PTGES3 Produits)

Synonymes: anticorps P23, anticorps TEBP, anticorps cPGES, anticorps PTGES3, anticorps 5730442A20Rik, anticorps Ptges, anticorps Tebp, anticorps p23, anticorps sid3177, anticorps RGD1561913, anticorps CPGES, anticorps cPGES-1, anticorps ptges3, anticorps wu:fb98d06, anticorps zgc:65804, anticorps zgc:77131, anticorps tebp, anticorps wu:fb50a04, anticorps zgc:86751, anticorps prostaglandin E synthase 3, anticorps prostaglandin E synthase 3 (cytosolic) pseudogene, anticorps prostaglandin E synthase 3a (cytosolic), anticorps prostaglandin E synthase 3 L homeolog, anticorps prostaglandin E synthase 3b (cytosolic), anticorps PTGES3, anticorps LOC743066, anticorps Ptges3, anticorps ptges3a, anticorps ptges3.L, anticorps ptges3b

Sujet: P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the hsp90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with hsp70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated hsp90 binding of client proteins (8). Since many hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.Synonyms: Cytosolic prostaglandin E2 synthase, Hsp90 co-chaperone, P23, Progesterone receptor complex p23, Prostaglandin E synthase 3, Telomerase-binding protein p23, cPGES

ID gène: 10728

UniProt: Q15185

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Cellular Glucan Metabolic Process