ALOX5AP anticorps

N° du produit ABIN4620366

Détail du produit anti-ALOX5AP anticorps

Antigène: ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALOX5AP est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects FLAP.
Cellular Localization: Nucleus membrane. Endoplasmic reticulum membrane.

Purification: Antigen Immunoaffiinity Chromatography

Immunogène: Synthetic peptide derived from Human FLAP protein

Information d'application

Indications d'application: Western blot (1: 400 starting dilution).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.08 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C. Can be shipped at 2-8 °C.

Détails sur ALOX5AP

Antigène: ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP))

Autre désignation: ALOX5AP / FLAP (ALOX5AP Produits)

Synonymes: anticorps fj65d02, anticorps zgc:63982, anticorps wu:fj65d02, anticorps flap, anticorps al5ap, anticorps Alox5ap, anticorps ALOX5AP, anticorps Flap, anticorps FLAP, anticorps arachidonate 5-lipoxygenase-activating protein, anticorps arachidonate 5-lipoxygenase activating protein, anticorps alox5ap, anticorps ALOX5AP, anticorps Alox5ap

Sujet: Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367], also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.Synonyms: Arachidonate 5-lipoxygenase-activating protein, MK-886-binding protein

ID gène: 241

NCBI Accession: NP_001191335

UniProt: P20292