KIR2DL1 anticorps (C-Term)

N° du produit ABIN2789507

Détail du produit anti-KIR2DL1 anticorps

Antigène: KIR2DL1 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 1 (KIR2DL1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIR2DL1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Séquence: DEQDPQEVTY TQLNHCVFTQ RKITRPSQRP KTPPTDIIVY TELPNAESRS

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against KIR2DL1. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 348 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur KIR2DL1

Antigène: KIR2DL1 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 1 (KIR2DL1))

Autre désignation: KIR2DL1 (KIR2DL1 Produits)

Synonymes: anticorps NKAT, anticorps NKAT1, anticorps p58.1, anticorps CD158A, anticorps KIR221, anticorps KIR-K64, anticorps killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1, anticorps killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1, anticorps KIR2DL1

Sujet: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
Alias Symbols: CD158A, KIR-K64, KIR221, NKAT, NKAT1, p58.1
Protein Interaction Partner: HLA-C,
Protein Size: 348

Poids moléculaire: 38 kDa

ID gène: 3802

NCBI Accession: NM_014218, NP_055033

UniProt: P43626