IL-31 anticorps (Center)

N° du produit ABIN303271

Détail du produit anti-IL-31 anticorps

Antigène: IL-31 (IL31) (Interleukin 31 (IL31))

Épitope: Center

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-31 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody reacts with Interleukin 31 (IL31).

Purification: Affinity Chromatography.

Immunogène: Synthetic Peptide corresponding to 18 amino acid peptide from near the center of human IL-31.

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.

Détails sur IL-31

Antigène: IL-31 (IL31) (Interleukin 31 (IL31))

Autre désignation: Interleukin-31 / IL31 (IL31 Produits)

Synonymes: anticorps IL-31, anticorps 1700013B14Rik, anticorps IL31, anticorps interleukin 31, anticorps IL31, anticorps Il31

Sujet: Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.Synonyms: IL-31

ID gène: 386653

NCBI Accession: NP_001014358

UniProt: Q6EBC2