CACNA1C anticorps

N° du produit ABIN306881

L’anticorps anti-CACNA1C Polyclonal Lapin est utilisé pour la détection de CACNA1C dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour CACNA1C anticorps (ABIN306881)

Antigène: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACNA1C est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CACNA1C anticorps

Fonction: Rabbit anti Human Calcium Channel

Réactivité croisée: Humain

Attributs du produit: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1g gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. alpha(1G) is most likely responsible for burst firing in thalamic relay cells. These neurons burst during various thalamocortical oscillations including absence seizures the modulation of the intrinsic firing pattern mediated by alpha(1G) T-type Ca(2+) channels plays a critical role in the genesis of absence seizures in the thalamocortical pathway.

Purification: Ammonium Sulfate Precipitation

Immunogène: Synthetic peptide derived from the rat alpha1G calcium channel conjugated to KLH

Isotype: IgG

Information d'application

Indications d'application: This antibody can be used for Western blotting (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur CACNA1C

Antigène: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Autre désignation: Calcium Channel

Sujet: Voltage-Dependent T-Type Calcium Channel, alpha1G subunit, Cncna1G

UniProt: O43497

Pathways: Hormone Transport, Carbohydrate Homeostasis