DEDD2 anticorps

N° du produit ABIN499734

Détail du produit anti-DEDD2 anticorps

Antigène: DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DEDD2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: DEDD2 antibody was raised against a peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.

Purification: Immunoaffinity chromatography purified IgG

Immunogène: Human DEDD2 Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 0.5 to 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur DEDD2

Antigène: DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Autre désignation: DEDD2 (DEDD2 Produits)

Synonymes: anticorps FLAME-3, anticorps MGC145883, anticorps 2410050E11Rik, anticorps DEDD2, anticorps death effector domain containing 2, anticorps death effector domain containing 2 L homeolog, anticorps death effector domain-containing DNA binding protein 2, anticorps DEDD2, anticorps dedd2.L, anticorps dedd2, anticorps Dedd2

Sujet: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain (1). A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD (2). More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD (2,3). Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis (3). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.Synonyms: DED-containing protein FLAME-3, DEDD-2, DNA-binding death effector domain-containing protein 2, FADD-like anti-apoptotic molecule 3, FLAME-3, FLAME3, PSEC0004

ID gène: 162989

NCBI Accession: NP_579874

UniProt: Q8WXF8