STING/TMEM173 anticorps (C-Term)

N° du produit ABIN500288

Détail du produit anti-STING/TMEM173 anticorps

Antigène: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STING/TMEM173 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody detects TMEM173 / STING.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Peptide Affinity Chromatography

Immunogène: TMEM173 antibody was raised against a 17 amino acid peptide near the carboxy terminus of Human TMEM173.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: (1-2 μg/mL). A-20 cell tissue lysate can be used as positive control. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur STING/TMEM173

Antigène: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Autre désignation: TMEM173 / STING (TMEM173 Produits)

Synonymes: anticorps ERIS, anticorps MITA, anticorps MPYS, anticorps NET23, anticorps STING, anticorps 2610307O08Rik, anticorps Mita, anticorps RGD1562552, anticorps transmembrane protein 173, anticorps TMEM173, anticorps Tmem173

Sujet: MPYS (TMEM173 / STING) is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.Synonyms: MITA, Mediator of IRF3 activation, Stimulator of interferon genes protein, Transmembrane protein 173

ID gène: 340061

NCBI Accession: NP_938023

UniProt: Q86WV6

Pathways: Activation of Innate immune Response