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Zhang, Li, Jiang, Yu, An: Enhanced endoplasmic reticulum SERCA activity by overexpression of hepatic stimulator substance gene prevents hepatic cells from ER stress-induced apoptosis. dans American journal of physiology. Cell physiology 2014
Akamatsu, Shibata, Ito, Sohma, Azuma, Otsuki: Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress. dans Anticancer research 2009
Pathophysiological studies showed that the overexpression of the CASP4 gene was involved in the loss of proximal tubules and renal injury in nephropathic cystinosis patients. Considering kidney's key roles in sodium filtration and reabsorption CASP4 genes are involved in Blood Pressure regulation.
We propose that microglial caspase-4 expression contributes to the cognitive impairments in Alzheimer's disease (AD), and that further study of caspase-4 will enhance our understanding of AD pathogenesis and may lead to novel therapeutic targets in AD.
this study shows that activation of caspase-4 is mediated by interactions with endotoxin-rich membrane interfaces rather than by endotoxin monomers
Specific activation of caspase-3 (Montrer CASP3 Kits ELISA) and caspase-4 was found in proplatelets. Consistent with previous observations of caspase-4 autoactivation in response to endoplasmic reticulum (ER) stress, several ER stress marker proteins were expressed during proplatelet formation.
apoptosis is induced by rhein traditional Chinese medicine via induction of endoplasmic reticulum stress, caspase-4 and intracellular calcium in primary human hepatic HL-7702 cells
Caspase-4 and caspase-5 (Montrer CASP5 Kits ELISA) mediate IL-1alpha and IL-1beta (Montrer IL1B Kits ELISA) release from human monocytes after lipopolysaccharides stimulation.
both caspase-4 and caspase-5 (Montrer CASP5 Kits ELISA) are functionally important for appropriate responses to intracellular Gram-negative bacteria.
caspase-4 activation alone is sufficient to induce pyroptosis, this process depends on the NLRP3 (Montrer NLRP3 Kits ELISA) inflammasome activation to drive IL-1beta (Montrer IL1B Kits ELISA) maturation.
This study reveled that CASP4 having a central role in the bipolar disease and schizophrenia manifestation.
NF-kappaB (Montrer NFKB1 Kits ELISA) can mediate Fas (Montrer FAS Kits ELISA)-induced apoptosis through caspase-4 protease
These data indicate that the caspase-11-mediated innate immune response plays a crucial role in defending against Acinetobacter baumannii.
Caspase-11 targets cofilin (Montrer CFL1 Kits ELISA) via the RhoA GTPase, whereas caspase-1 (Montrer CASP1 Kits ELISA) engages the Slingshot phosphatase
Hyperactive dendritic cells induce potent adaptive immune responses and are elicited by caspase-11, an enzyme that binds oxidized phospholipids and bacterial lipopolysaccharide.
Caspase-1 (Montrer CASP1 Kits ELISA)-activated IL-18 (Montrer IL18 Kits ELISA) induces IFN-gamma (Montrer IFNG Kits ELISA) to prime caspase-11 and rapidly clear Burkholderia thailandensis infection.
These results argue that caspase-1 (Montrer CASP1 Kits ELISA), -4 or -5 can be recruited to inflammasomes under specific circumstances, often leading to distinctly organized and localized complexes that may impact the functions of these proteases
gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation
But not in Casp11(-/-), Panx1 (Montrer PANX1 Kits ELISA)(-/-), or P2x7 (Montrer P2RX7 Kits ELISA)(-/-) mice.
active caspase-11 leads to a drop of intracellular potassium levels, which is necessary to activate NLRP3 (Montrer NLRP3 Kits ELISA).
Data show that caspase-1 (Montrer CASP1 Kits ELISA) but not caspase-11 was essential for the functional activities of the NLRC4 (Montrer NLRC4 Kits ELISA) inflammasome.
Data indicate that genetic ablation of caspase-1 (Montrer CASP1 Kits ELISA) and -11 from cpdm (Montrer SHARPIN Kits ELISA) mice significantly reduced skin inflammation in sharpin (Montrer SHARPIN Kits ELISA)-deficient mice.
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
, apoptotic cysteine protease Mih1/TX
, caspase 4, apoptosis-related cysteine protease
, protease ICH-2
, protease TX
, caspase 11, apoptosis-related cysteine peptidase
, caspase 11, apoptosis-related cysteine protease
, caspase-11 short form splicing
, protease ICH-3
, caspase 11
, IL-1 beta-converting enzyme
, caspase-1/caspase-4 hybrid
, interleukin-1 beta convertase
, interleukin-1 beta-converting enzyme
, caspase 13
, evolutionary related interleukin-1-beta-converting enzyme