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These results suggest that CT acts as a hypocalcemic factor in calcium regulation, probably through inhibition of ECaC (Montrer TRPV6 Kits ELISA) synthesis.
crlr (Montrer CALCRL Kits ELISA) plays a nonredundant role in arterial differentiation, representing a novel element of the sonic hedgehog (Montrer SHH Kits ELISA)-vegf (Montrer VEGFA Kits ELISA)-notch (Montrer NOTCH1 Kits ELISA) signaling cascade that controls arterial/venous fate
structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Galphasbetagamma protein determined by Volta phase-plate single-particle cryo-electron microscopy
Data suggest that a single GlcNAc residue at CTR N130 (asparagine 130) is responsible for enhanced affinity of calcitonin (Montrer CALCA Kits ELISA) for CTR ECD (Montrer SHFM1 Kits ELISA); the same appears to apply for enhanced affinity of amylin (Montrer IAPP Kits ELISA) for RAMP2 (Montrer RAMP2 Kits ELISA)-CTR ECD (Montrer SHFM1 Kits ELISA). [GlcNAc = N-acetylglucosamine; CTR = calcitonin receptor; ECD (Montrer SHFM1 Kits ELISA) = extracellular domain; RAMP2 (Montrer RAMP2 Kits ELISA) = receptor (calcitonin) activity modifying protein 2 (Montrer RAMP2 Kits ELISA)].
Males with CALCR TT genotype (rs1801197) have 13 fold increased risk for kidney stone disease. No significant association of rs1042138 with kidney stone in West Bengal, India.
Calcitonin (Montrer CALCA Kits ELISA) and Amylin (Montrer IAPP Kits ELISA) Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.
An association between fluorosis and the Alu I polymorphism in the CTR gene was observed in fluoride-exposed populations.
The C1377T polymorphism in the CTR gene is associated with bone mineral density at the lumbar spine in a postmenopausal Han Chinese population
There was no statistically significant difference in CTR gene nucleotide sequence polymorphisms at 1377-bp between Chinese Xinjiang Han and Uygur patients with primary osteoporosis.
Data indicate a potential association between 3'UTR (Montrer UTS2R Kits ELISA)+18C>T and intron 1 polymorphisms in the CALCR and the risk of kidney stone disease.
Prolonged calcitonin receptor signaling by salmon, but not human calcitonin (Montrer CALCA Kits ELISA), reveals ligand bias.
High calcitonin receptor is associated with prostate cancer.
the expression of CTR is associated with the early cellular events involved in atherosclerotic plaque formation and is down-regulated as stabilisation of plaque progresses in the process of healing.
Calcr knockout resulted in abnormal quiescent state of muscle stem cells, reduction of their pool apoptosis and relocation from the MSC (Montrer MSC Kits ELISA) niche.
data suggest that Clr-b (Montrer CLEC2D Kits ELISA) modulation is a conserved innate host cell response to virus infection that is subverted by multiple CMV immune evasion strategies.
upregulated in synovial tissue of osteoarthritic mice by macrophage-derived IL-1 beta (Montrer IL1B Kits ELISA)
Together, these data indicate that signaling through RAMP1 (Montrer RAMP1 Kits ELISA) and CLR plays a role in mediating asthma pathology
The relevance of the OPG (Montrer TNFSF11 Kits ELISA)/RANK/RANKL (Montrer TNFSF11 Kits ELISA) system in the particle-induced osteolysis process, was investigated.
Nkrp1-Clr gene cluster appears to evolve more slowly relative to the related Ly49 cluster, and likely regulates innate immunosurveillance in a tissue-specific manner
Odz4 is expressed in quiescent satellite cells, like calcitonin receptor, but the timing of the reappearance of these genes is different during regeneration.
The perinatal expression of CTR within the ENS suggests that the calcitonin (Montrer CALCA Kits ELISA)/CTR system may have a role in the maturation of enteric neurons
CGRP-receptor component protein (Montrer CRCP Kits ELISA) has been found to interact only with calcitonin (Montrer CALCA Kits ELISA)-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide (Montrer CALCA Kits ELISA) signaling.
CTR protects against hypercalcemia predominantly via its inhibitory action on osteoclasts.
Intracoronary intermedin (Montrer ADM2 Kits ELISA) 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin (Montrer CALCA Kits ELISA) receptors and beta-adrenoreceptor-mediated nitric oxide release.
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants.
, calcitonin receptor-like