Aperçu des produits pour anti-Topoisomerase II alpha (TOP2A) Anticorps

Full name:
anti-Topoisomerase (DNA) II alpha 170kDa Anticorps (TOP2A)
Chez www.anticorps-enligne.fr sont 267 Topoisomerase (DNA) II alpha 170kDa (TOP2A) Anticorps de 22 de différents fournisseurs disponibles. De plus, nous expédions Topoisomerase II alpha Kits (23) et Topoisomerase II alpha Protéines (3) et beaucoup plus de produits pour cette protéine. Un total de 295 Topoisomerase II alpha produits sont actuellement listés.
Synonymes:
D230016L12Rik, TOP-2, TOP2, TOP2A, TP2A

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anti-Topoisomerase II alpha Anticorps mieux référencés

  1. Human Monoclonal Topoisomerase II alpha Primary Antibody pour WB - ABIN1109282 : Yoshida, Yamaguchi, Shinagawa, Taira, Nakayama, Miki: Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage. dans Molecular and cellular biology 2006 (PubMed)
    Show all 8 references for 1109282

  2. Human Monoclonal Topoisomerase II alpha Primary Antibody pour IHC (p), IP - ABIN1109281 : Kaplan, Greenlund, Tanner, Shaw, Schreiber: Identification of an interferon-gamma receptor alpha chain sequence required for JAK-1 binding. dans The Journal of biological chemistry 1996 (PubMed)
    Show all 7 references for 1109281

  3. Human Polyclonal Topoisomerase II alpha Primary Antibody pour EIA, WB - ABIN955291 : Vranic, Frkovic-Grazio, Lamovec, Serdarevic, Gurjeva, Palazzo, Bilalovic, Lee, Gatalica: Adenoid cystic carcinomas of the breast have low Topo IIα expression but frequently overexpress EGFR protein without EGFR gene amplification. dans Human pathology 2010 (PubMed)
    Show all 5 references for 955291

  4. Human Polyclonal Topoisomerase II alpha Primary Antibody pour ELISA, WB - ABIN1533131 : Lang, Mirski, Cummings, Yu, Gerlach, Cole: Structural organization of the human TOP2A and TOP2B genes. dans Gene 1998 (PubMed)

  5. Human Polyclonal Topoisomerase II alpha Primary Antibody pour EIA, IF - ABIN955290 : Kawamura, Pope, Christensen, Sun, Terekhova, Boege, Mielke, Andersen, Marko: Mitotic chromosomes are constrained by topoisomerase II-sensitive DNA entanglements. dans The Journal of cell biology 2010 (PubMed)

Plus d’anticorps contre Topoisomerase II alpha partenaires d’interaction

Mouse (Murine) Topoisomerase (DNA) II alpha 170kDa (TOP2A) interaction partners

  1. Polyamide functionalisation at the N1-position offers a design strategy to improve drug-like properties. Dicationic HxIP* 3 increased topo IIalpha expression and chemosensitivity to topo II (Montrer TOP2 Anticorps)-targeting agents.

  2. We demonstrated that Nup98 (Montrer NUP98 Anticorps)-TopIIbeta and Nup98 (Montrer NUP98 Anticorps)-SETBP1 (Montrer SETBP1 Anticorps) negatively regulate the XPO1 (Montrer XPO1 Anticorps)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98 (Montrer NUP98 Anticorps)-fusion proteins induce tumorigenesis.

  3. TOP2 (Montrer TOP2 Anticorps) and BAF (Montrer BANF1 Anticorps) cooperate to recruit pluripotency factors, which explains some of the instructive roles of BAF (Montrer BANF1 Anticorps) complexes.

  4. Deletion or deficiency of PTEN (Montrer PTEN Anticorps) leads to down regulation of TOP2A, dysfunction of the decatenation checkpoint and incomplete DNA decatenation in G2 and M phases.

  5. Inhibition of DNA topoisomerase II (Montrer TOP2 Anticorps) selectively reduces the threat of tumorigenicity

  6. Cohesin removal is a prerequisite for the posterior topoisomerase IIalpha-mediated resolution of persisting catenations between segregating chromatids during anaphase II.

  7. Data show that unfolded protein response (UPR)-induced changes in topoisomerase IIalpha (Topo IIalpha) protein levels are not responsible for resistance to etoposide, and that the PERK plays a Topo IIalpha-independent role in altered sensitivity to the drug.

  8. TOP2beta (Montrer TOP2B Anticorps) as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.

  9. Topoisomerase IIa not only contributes to stem-cell transcriptome regulation but also primes developmental genes for subsequent activation upon differentiation.

  10. studies indicate that the ability of TOP2A to prevent DNA entanglement at mitosis requires BAF (Montrer BANF1 Anticorps) complexes and suggest that this activity contributes to the role of BAF (Montrer BANF1 Anticorps) subunits as tumour suppressors

Human Topoisomerase (DNA) II alpha 170kDa (TOP2A) interaction partners

  1. Tumors with higher topoisomerase IIalpha and/or mitosin (Montrer CENPF Anticorps) expression have a higher risk of recurrence after initial treatment, and these patients may benefit from adjuvant treatment and closer radiological follow-up

  2. Both the genome instability and cell death of MRE11 (Montrer MRE11A Anticorps)-null and MRE11 (Montrer MRE11A Anticorps)-mutated H129N cells are significantly reversed by overexpression of Tdp2 (Montrer TDP2 Anticorps), an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 (Montrer MRE11A Anticorps) nuclease (Montrer DCLRE1C Anticorps) activity is likely to remove the DNA lesions.

  3. we show that TopoIIalpha forms protein-protein interactions with beta-catentin and TCF4 (Montrer TCF4 Anticorps) and interacts with Wnt (Montrer WNT2 Anticorps) response elements (WREs) and promoters of direct target genes of TCF (Montrer HNF4A Anticorps) transcription, including: MYC (Montrer MYC Anticorps), vimentin (Montrer VIM Anticorps), AXIN2 (Montrer AXIN2 Anticorps) and LEF1 (Montrer LEF1 Anticorps)

  4. This study shows that both survivin (Montrer BIRC5 Anticorps) and TIIalpha are independent prognostic predictors in human grade II/III astrocytomas stratified for IDH1 (Montrer IDH1 Anticorps)-mutation status

  5. Polyamide functionalisation at the N1-position offers a design strategy to improve drug-like properties. Dicationic HxIP* 3 increased topo IIalpha expression and chemosensitivity to topo II (Montrer TOP2 Anticorps)-targeting agents.

  6. BD ProExtrade mark C assay containing MCM2 (Montrer MCM2 Anticorps) and TOP2A antibodies showed strong specific nuclear staining that correlated with increased cervical dysplasia and lesion severity.

  7. Fbxo28 (Montrer FBXO28 Anticorps) regulates topoisomerase IIalpha decatenation activity and plays an important role in maintaining genomic stability.

  8. TOP2A rs471692 was not associated with chemoradiotherapy response, whereas tumor regression, weight loss, clinical stage, and cigarette smoking were independent prognostic predictors for these Chinese patients with non-small cell lung cancer.

  9. we propose that phosphorylation of TOP2A by CDC7 (Montrer CDC7 Anticorps)/DBF4 (Montrer DBF4 Anticorps) in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A function could be relevant to prevent premature separation of centromeric DNA.

  10. Data indicate that cortex involvement, lower World Health Organization grade and DNA topoisomerase II (Montrer TOP2 Anticorps) positivity were strong predictors for preoperative epileptic seizures.

Topoisomerase II alpha (TOP2A) profil antigène

Antigen Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Alternative names and synonyms associated with Topoisomerase II alpha (TOP2A)

  • DNA topoisomerase II, alpha isozyme (TOP2A) anticorps
  • DNA topoisomerase II, alpha isozyme (Bm1_08705) anticorps
  • topoisomerase (DNA) II alpha (Top2a) anticorps
  • topoisomerase (DNA) II alpha 170kDa (TOP2A) anticorps
  • topoisomerase (DNA) II beta (Top2b) anticorps
  • topoisomersae II (TOPOII) anticorps
  • D230016L12Rik anticorps
  • TOP-2 anticorps
  • TOP2 anticorps
  • TOP2A anticorps
  • TP2A anticorps

Protein level used designations for TOP2A

DNA topoisomerase II, alpha isozyme , DNA Topoisomerase II alpha , DNA topoisomerase 2-alpha , topoisomerase (DNA) 2 alpha , DNA gyrase , DNA topoisomerase (ATP-hydrolyzing) , DNA topoisomerase II, 170 kD , DNA topoisomeraseII_alpha , DNA topoisomerase 2-beta , DNA topoisomerase II, beta isozyme

GENE ID SPECIES
700707 Macaca mulatta
6096668 Brugia malayi
21973 Mus musculus
360243 Rattus norvegicus
100689304 Cricetulus griseus
7153 Homo sapiens
480525 Canis lupus familiaris
395570 Gallus gallus
787696 Bos taurus
21974 Mus musculus
396917 Sus scrofa
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