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Human Polyclonal HDAC6 Primary Antibody pour IHC, WB - ABIN223301
Wang, Nguyen, McLaughlin, Sikkink, Ramirez-Alvarado, Weinshilboum: Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. dans Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 3 Pubmed References
Human Polyclonal HDAC6 Primary Antibody pour ChIP, WB - ABIN2668292
Ying, Zhang, Zhou, Qu, Wang, Liu, Lu, Zhu: Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. dans PLoS ONE 2012
Show all 3 Pubmed References
Human Polyclonal HDAC6 Primary Antibody pour IHC (p), WB - ABIN387955
Hook, Orian, Cowley, Eisenman: Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. dans Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Monoclonal HDAC6 Primary Antibody pour FACS, ICC - ABIN4316769
Sirchia, Faversani, Rovina, Russo, Paganini, Savi, Augello, Rosso, Del Gobbo, Tabano, Bosari, Miozzo: Epigenetic effects of chromatin remodeling agents on organotypic cultures. dans Epigenomics 2016
Human Polyclonal HDAC6 Primary Antibody pour ELISA - ABIN564313
Xargay-Torrent, López-Guerra, Saborit-Villarroya, Rosich, Campo, Roué, Colomer: Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Human Monoclonal HDAC6 Primary Antibody pour ELISA, WB - ABIN564314
Bantscheff, Hopf, Savitski, Dittmann, Grandi, Michon, Schlegl, Abraham, Becher, Bergamini, Boesche, Delling, Dümpelfeld, Eberhard, Huthmacher, Mathieson, Poeckel, Reader, Strunk, Sweetman, Kruse et al.: Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. ... dans Nature biotechnology 2011
Human Polyclonal HDAC6 Primary Antibody pour ChIP, IP - ABIN4316760
Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. dans Molecular and cellular biology 2005
that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2 (Montrer PLIN2 Anticorps)
HDAC6 is necessary and sufficient for BRP (Montrer GDF5 Anticorps) deacetylation. HDAC6 promotes the formation of larger presynaptic densities.
Atrial fibrillation induces remodeling and loss of contractile function, at least in part through HDAC6 activation and subsequent derailment of alpha-tubulin (Montrer TUBA4A Anticorps) proteostasis and disruption of the cardiomyocyte microtubule structure.
From a genetic screen, we found that a histone deacetylase 6 (HDAC6) null mutation rescued tau-induced MT defects in both muscles and neurons.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
Data suggest that alpha-synuclein inclusion formation in the presence of HDAC6 protects dopamine neurons from being damaged by oligomers, which may uncover a common mechanism for synucleinopathies.
findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy
Findings indicate that HDAC6 facilitates degradation of potentially noxious protein substrates, contributing vitally to the neuroprotective role of autophagy.
Results suggest that atrophin recruits histone deacetylases 1 and 2 and G9a (Montrer EHMT2 Anticorps) to modify histone H3K9 and to determine cell fates.
Study detected evidence that recent strongly positive selection has been acting on a 2.7-kb region in an ancestral African population; this region overlaps with the 3' end of HDAC6, a gene that encodes a newly characterized stress surveillance factor.
The HDAC6 Inhibitor Tubacin Induces Release of CD133(+) Extracellular Vesicles From Cancer Cells.
MicroRNA-22 Promoted Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting HDAC6
A decrease of HDAC6 expression caused by Helicobacter pylori infection is associated with oncogenic transformation in gastric cancer.
these results suggest that HDAC1 (Montrer HDAC1 Anticorps) and HDAC6 may play a role in clear cell renal cell carcinoma (Montrer MOK Anticorps) biology
Genetic abrogation of HDAC6 in primary melanoma (Montrer CD274 Anticorps) samples and cell lines, down-regulates the expression of PD-L1, an important co-stimulatory molecule expressed in cancer cells, which activates the inhibitory regulatory pathway PD-1 in T-cells.
activation appears to be a key survival mechanism for HDAC6 inhibitor treatment.
ARID1A (Montrer ARID1A Anticorps) mutation inactivates the apoptosis-promoting function of p53 (Montrer TP53 Anticorps) by upregulating HDAC6, indicating that pharmacological inhibition of HDAC6 is a therapeutic strategy for ARID1A (Montrer ARID1A Anticorps)-mutated cancers.
7-amino-4-methylcoumarin did not affect acetyllysine preference in a multiply acetylated substrate. In contrast, AMC significantly enhanced KDAC6 substrate affinity, greatly reduced Sirt1 (Montrer SIRT1 Anticorps) activity, eliminated the substrate sequence specificity of KDAC4, and had no consistent effect with KDAC8 substrates.
deacetylation of MST1 mediated by HBXIP-enhanced HDAC6 results in MST1 degradation in a chaperone-mediated autophagy (CMA). manner in promotion of breast cancer growth.
Suggest that HDAC4 (Montrer HDAC4 Anticorps) and HDAC6 are guardians of irradiation-induced DNA damage and stemness, thus promoting radioresistance in glioblastoma cells.
MAP3K4 (Montrer MAP3K4 Anticorps) activity controls epithelial-to-mesenchymal transition through the ubiquitination and degradation of HDAC6.
HDAC6 is a critical regulator of a pro-apoptotic p53 (Montrer TP53 Anticorps) K120 acetylation and mitochondrial function in mesenchymal stem cells
HDAC6 inhibition reduces cell growth primarily by reducing intracellular cAMP and Ca(2 (Montrer CA2 Anticorps)+) levels.
These data thus reveal that HDAC6 represses IL-17 (Montrer IL17A Anticorps) production in T cells, providing novel insights into the role of HDAC6 in the immune system.
HDAC6 inhibition reduces tumor growth and PD-L1 (Montrer CD274 Anticorps) production in vivo.
Specific HDAC6 inhibitor, tubacin, reduced cyst growth by inhibiting proliferation of cyst-lining epithelial cells, downregulated cyclic AMP (Montrer TMPRSS5 Anticorps) levels, and improved renal function in mouse model of autosomal dominant polycystic kidney disease (ADPKD). Thus, HDAC6 could play a role in cyst formation and could serve as a potential therapeutic target in ADPKD.
Data suggest that a switch in post-translational processing of Tau from acetylation at Lys321 to phosphorylation at Ser324 coordinately regulates Tau aggregation and may be relevant in tauopathy and Alzheimer disease; acetylation/phosphorylation of Tau appears to be controlled by Hdac6 (histone deacetylase 6 protein).
Fatty acids prevent CIDEC (Montrer CIDEC Anticorps) deacetylation by promoting the dissociation of CIDEC (Montrer CIDEC Anticorps) from HDAC6, resultin in increased association of CIDEC (Montrer CIDEC Anticorps) with PCAF (Montrer KAT2B Anticorps) on the endoplasmic reticulum.
In coordination with increased HDAC6 phosphorylation, cigarette smoke extract inhibited Akt (Montrer AKT1 Anticorps) and activated glycogen synthase kinase (GSK)-3beta (Montrer GSK3b Anticorps).
The results suggest that HSI2 recruits MED13 (Montrer MED13 Anticorps) and HDA6 to suppress directly a subset of seed maturation genes post-germination.
HDA6 is a component of the TRB2 (Montrer TRIB2 Anticorps) complex.
Our results indicate that AtMBD6 is involved in RNA-mediated gene silencing and it binds to RNA binding proteins like AtRPS2C, AtAGO4 and AtNTF2. AtMBD6 also interacts with histone deacetylase AtHDA6 that might have a role in chromatin condensation at the targets of RdDM
HDA6 has at least two clearly separable activities in different genomic regions. In addition, we present an unexpected role for HDA6 in the control of DNA methylation (Montrer HELLS Anticorps) at CG dinucleotides.
Data show that both transcript levels and expression patterns of ENHANCER OF TRIPTYCHON AND CAPRICE1 (ETC1 (Montrer CD86 Anticorps)) in the root tip were affected in hda6 mutation.
HDC1 is a ubiquitously expressed nuclear protein (Montrer UBN1 Anticorps) that interacts with at least two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.
HDA6 and FLD (Montrer LPIN1 Anticorps) could act together in a protein complex. Increased levels of histone H3 acetylation and H3K4 trimethylation, indicating functional interplay between histone deacetylase and demethylase (Montrer MBD2 Anticorps) through HDA6 and FLD (Montrer LPIN1 Anticorps) interaction in flowering control.
Taken together, these data indicate that HDA6 is a part of the AS1 repressor complex to regulate the KNOX expression in leaf development.
HD2C functionally associates with HDA6 and regulates gene expression through histone modifications.
HDA6 and MET1 (Montrer DNMT1 Anticorps) interact directly and act together to silence transposable elements by modulating DNA methylation (Montrer HELLS Anticorps), histone acetylation, and histone methylation status.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
, histone deacetylase 6
, histone deacetylase HDA2
, histone deacetylase 5
, histone deacetylase mHDA2
, scurfy candidate 6