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Aperçu des produits pour anti-PPP1R12A (PPP1R12A) Anticorps

Full name:
anti-Myosin Phosphatase, Target Subunit 1 Anticorps (PPP1R12A)
Chez www.anticorps-enligne.fr sont 96 Myosin Phosphatase, Target Subunit 1 (PPP1R12A) Anticorps de 15 de différents fournisseurs disponibles. De plus, nous expédions PPP1R12A Kits (6) et PPP1R12A Protéines (4) et beaucoup plus de produits pour cette protéine. Un total de 115 PPP1R12A produits sont actuellement listés.
Synonymes:
1200015F06Rik, 5730577I22Rik, AA792106, AV099298, D10Ertd625e, M110, M130, MBS, MBSP, MYPT1

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anti-Mouse (Murine) PPP1R12A Anticorps:

anti-Human PPP1R12A Anticorps:

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anti-PPP1R12A Anticorps mieux référencés

  1. Human Monoclonal PPP1R12A Primary Antibody pour WB - ABIN968767 : Chen, Chen, Alessi, Campbell, Shanahan, Cohen, Cohen: Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M. dans FEBS letters 1995 (PubMed)
    Show all 3 references for ABIN968767

Plus d’anticorps contre PPP1R12A partenaires d’interaction

Mouse (Murine) Myosin Phosphatase, Target Subunit 1 (PPP1R12A) interaction partners

  1. Mypt1 E24 splice variants tune arterial reactivity and could be worthy targets for lowering vascular resistance in disease states.

  2. revealed the presence of two MYPT1 isoforms, full length and variant 2 in human intestinal (Caco-2) epithelial cells and isolated intestinal epithelial cells from mice

  3. phosphorylation of MYPT1 T694, but not T852, mediates force maintenance in bladder smooth muscle.

  4. Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle

  5. Maturation of mesenteric artery smooth muscle involves TRA2beta (Montrer TRA2B Anticorps) mediated Mypt1 exon 24 splicing.

  6. The role of MYPT1 in vascular smooth muscle was investigated in adult MYPT1 smooth muscle specific knock-out mice. MYPT1 deletion enhanced phosphorylation of myosin regulatory light chain and contractile force in isolated mesenteric arteries.

  7. MYPT1 is not essential for smooth muscle function in mice but regulates the Ca(2 (Montrer CA2 Anticorps)+) sensitivity of force development and contributes to intestinal phasic contractile phenotype.

  8. Tra2beta (Montrer TRA2B Anticorps), by regulating the splicing of Mypt1 E23, sets the sensitivity of smooth muscle to cGMP-mediated relaxation.

  9. Organ-specific mechanisms involving MYPT1, M-RIP (Montrer MPRIP Anticorps), and CPI-17 (Montrer PPP1R14A Anticorps) are critical to regulating basal LC20 (Montrer MYL9 Anticorps) phosphorylation in gastrointestinal smooth muscles.

  10. Findings define a new conserved pathway in which sexual development and pregnancy mediate smooth and striated (Montrer NSDHL Anticorps) muscle adaptations through SMTNL1 and MYPT1.

Human Myosin Phosphatase, Target Subunit 1 (PPP1R12A) interaction partners

  1. Study revealed the presence of two MYPT1 isoforms, full length and variant 2 in human intestinal (Caco-2) epithelial cells and isolated intestinal epithelial cells from mice.

  2. These results indicate that PPP1R12A indeed plays a role in skeletal muscle insulin (Montrer INS Anticorps) signaling

  3. the relative expression of LZ+/LZ (Montrer LYZ Anticorps)- MYPT1 isoforms, in part, defines the vascular response to NO and NO based vasodilators, and therefore, plays a role in the regulation of vascular tone in both health and disease

  4. Expression of NUAK1 (Montrer NUAK1 Anticorps) is controlled by cyclin-dependent kinase (Montrer CDK1 Anticorps), PLK1 (Montrer PLK1 Anticorps), and the SCFbetaTrCP (Skp, Cullin and F-boxbetaTrCP) E3 ubiquitin ligase (Montrer MUL1 Anticorps) complex.

  5. distinct roles of two inhibitory phosphorylation sites of MYPT1

  6. in apoptotic cells, the myosin-binding domain of myosin phosphatase targeting subunit 1 is cleaved by caspase-3, and the cleaved MYPT1 is strongly phosphorylated at Thr-696 and Thr-853, phosphorylation of which is known to inhibit myosin II binding

  7. results suggested that during atherosclerosis progression oxidative stress mediates the downregulation of MYPT1, which may inhibit smooth muscle cell migration and contribute to the aberrant contractility

  8. Calcineurin (Montrer PPP3CA Anticorps) may modulate the phosphorylation level of MLC20 (Montrer MYL12B Anticorps) by influencing the phosphorylation state of MYPT1 to regulate endothelial barrier function.

  9. Mypt1 colocalizes outside the nucleus with Nkx2.5 in a manner dependent on Wnt signaling and Rho-associated protein kinase.

  10. These findings provide evidence for the involvement of a particular PP1 (Montrer PPA1 Anticorps) complex, PPP1R12A/PP1cdelta, in insulin (Montrer INS Anticorps) signaling.

PPP1R12A profil antigène

Antigen Summary

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PPP1R12A

  • protein phosphatase 1, regulatory (inhibitor) subunit 12A (Ppp1r12a) anticorps
  • protein phosphatase 1, regulatory subunit 12A (PPP1R12A) anticorps
  • protein phosphatase 1, regulatory subunit 12A (Ppp1r12a) anticorps
  • 1200015F06Rik anticorps
  • 5730577I22Rik anticorps
  • AA792106 anticorps
  • AV099298 anticorps
  • D10Ertd625e anticorps
  • M110 anticorps
  • M130 anticorps
  • MBS anticorps
  • MBSP anticorps
  • MYPT1 anticorps

Protein level used designations for PPP1R12A

myosin phosphatase target subunit 1 , myosin phosphatase, target subunit 1 , myosin phosphatase-targeting subunit 1 , protein phosphatase 1 regulatory subunit 12A , myosin binding subunit , protein phosphatase 1, regulatory (inhibitor) subunit 12A , protein phosphatase myosin-binding subunit , PP-1M , protein phosphatase subunit 1M , serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110 , smooth muscle myosin phosphatase myosin-binding subunit , 130 kDa myosin-binding subunit of smooth muscle myosin phophatase , 130 kDa myosin-binding subunit of smooth muscle myosin phosphatase , 133kDa myosin-binding subunit of smooth muscle myosin phosphatase (M133) , PP1M subunit M110

GENE ID SPECIES
17931 Mus musculus
4659 Homo sapiens
116670 Rattus norvegicus
396020 Gallus gallus
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