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anti-Human alpha Adducin Anticorps:
anti-Mouse (Murine) alpha Adducin Anticorps:
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Human Polyclonal alpha Adducin Primary Antibody pour WB - ABIN2801956
Joshi, Gilligan, Otto, McLaughlin, Bennett: Primary structure and domain organization of human alpha and beta adducin. dans The Journal of cell biology 1991
Show all 4 Pubmed References
The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with Essential Hypertension risk in a Caucasian population from Madeira Island.
ZNF322A (Montrer ZNF322A Anticorps) overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis
ADD1 rs4963 polymorphism showed an increased hypertension risk.
This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus.
Study shows that ADD1-rs4963 conferred susceptibility to colorectal cancer (CRC (Montrer CALR Anticorps)) suggesting an association between ADD1 and CRC (Montrer CALR Anticorps) risk.
The T allele of ADD1 is associated with essential hypertension in Asians.
study of potential effects of interaction between DNA methylation (Montrer HELLS Anticorps) of ADD1 promoter and ADD1 tagSNPs and environmental factors on essential hypertension (EH); results indicate ADD1 SNP rs4961 has a protective role in development of EH; interactions between alcohol consumption and DNA methylation (Montrer HELLS Anticorps) of ADD1 gene promoter have a significant role in modifying EH susceptibility
There were significant differences between the control group and pediatric hypertensive group in terms of ACE (Montrer ACE Anticorps) I/D (P<0.05) and AGT (Montrer AGXT Anticorps) M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.
A significant association was found between ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies need to be done to confirm these findings in a large sample.
When alpha-adducin complexes with sodium potassium ATPase (Montrer DNAH8 Anticorps) in astrocytes, non-cell autonomous neurodegeneration is triggered.
Data show that miR (Montrer MLXIP Anticorps)-200b and miR (Montrer MLXIP Anticorps)-200c could directly bind the 3' UTR (Montrer UTS2R Anticorps) of JUN (Montrer JUN Anticorps), and JUN (Montrer JUN Anticorps) activated the transcription of srebp1 (Montrer SREBF1 Anticorps) to increase lipid accumulation.
a novel role for SREBP-1 (Montrer SREBF1 Anticorps) as a cell surface retention factor for TbetaRI (Montrer TGFBR1 Anticorps) in mesangial cells, is reported.
Srebp1c (Montrer SREBF1 Anticorps) is a key regulator of metabolic remodeling leading to the beneficial effects of caloric restriction.
The present study indicates a requirement for C/EBPbeta (Montrer CEBPB Anticorps) in the insulin (Montrer INS Anticorps)-mediated induction of SREBP-1c (Montrer SREBF1 Anticorps) mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha (Montrer NR1H3 Anticorps), our data reported herein indicate a requirement for both transcription factors.
Sez6l2 (Montrer SEZ6L2 Anticorps) is one of the auxiliary subunits of the AMPA (Montrer GRIA3 Anticorps) receptor and acts as a scaffolding protein to link GluR1 (Montrer GRIA1 Anticorps) to ADD. Furthermore, Sez6l2 (Montrer SEZ6L2 Anticorps) overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 (Montrer SEZ6L2 Anticorps) modulates AMPA (Montrer GRIA3 Anticorps)-ADD signal transduction.
The deletion of Srebf-2 (Montrer SREBF2 Anticorps) and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR (Montrer NR1H3 Anticorps) activity and SREBP-1c (Montrer SREBF1 Anticorps) expression.
The fasting-induced transcription factor KLF15, a key regulator of gluconeogenesis, forms a complex with LXR (Montrer NR1H3 Anticorps)/RXR, specifically on the Srebf1 (Montrer TOM1L2 Anticorps) promoter.
Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 (Montrer NFE2L2 Anticorps) recruitment to the Srebp-1c (Montrer SREBF1 Anticorps) promoter in livers of BPA (Montrer DST Anticorps)-exposed mice was observed.
Reduction in ADD1 protein in NEK1 (Montrer NEK1 Anticorps) mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 (Montrer MYO10 Anticorps) during meiotic spindle formation
suggesting a specific effect of sterol regulatory element binding protein (Montrer CNBP Anticorps)-1c on neurosteroidogenesis
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms\; however, not all variants have been fully described.
adducin 1 (alpha)
, adducin 2 (beta)
, erythrocyte adducin alpha subunit
, erythrocyte adducin subunit alpha
, adipocyte determination- and differentiation-dependent factor 1
, sterol regulatory element-binding protein 1