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Data suggest that GCGR (glucagon receptor (Montrer GCGR Kits ELISA)) activation proceeds via a mechanism in which transmembrane helix 6 (TM6) is held in an inactive conformation by a conserved polar core and a hydrophobic lock (involving intracellular loop 3, IC3); mutations in the corresponding polar core of GCGR (Montrer GCGR Kits ELISA) or PAC1R disrupt these inhibitory elements, allow TM6 to swing outward, and induce constitutive G protein signaling.
Results confirmed for the first time that doxycycline specially targeted pituitary adenylate cyclase-activating polypeptide (PACAP (Montrer ADCYAP1 Kits ELISA)) receptor type 1 (PAC1) imitating PACAP (Montrer ADCYAP1 Kits ELISA)(30-37) and acted as an enhancer by facilitating the subsequent ligand binding and the activation of PAC1.
Data show that glucocorticoid response genes NR3C1 (Montrer NR3C1 Kits ELISA), ADCYAP1R1 and HSD11B2 (Montrer HSD11B2 Kits ELISA) were relatively hypomethylated whereas FKBP5 (Montrer FKBP5 Kits ELISA) was hypermethylated.
High child stress and an ADCYAP1R1 single-nucleotide polymorphism are associated with reduced bronchodilator response in children with asthma.
and its receptor (PAC1) are involved in stress response and anxiety.
PAC1/PACAP (Montrer ADCYAP1 Kits ELISA) receptor endocytosis contributes to ERK (Montrer EPHB2 Kits ELISA) acktivation.
Individual differences in ADCYAP1R1 genotype may contribute to dysregulated fear circuitry known to play a central role in posttraumatic stress disorder and other anxiety disorders.
Data indicate that VIP (Montrer Vip Kits ELISA) and PACAP (Montrer ADCYAP1 Kits ELISA) increased macrophage resistance to HIV-1 replication by inducing the synthesis of beta-chemokines CCL3 (Montrer CCL3 Kits ELISA) and CCL5 (Montrer CCL5 Kits ELISA) and IL-10 (Montrer IL10 Kits ELISA) following preferential activation of the receptors VPAC2 (Montrer VIPR2 Kits ELISA) and PAC1.
The findings suggest that the PACAP (Montrer ADCYAP1 Kits ELISA)-PAC1 receptor pathway may play an important role in female human responses to traumatic stress
ADCYAP1R1 genotype may have a role in post-traumatic stress symptoms in highly traumatized African-American females
The results suggested that sympathetic nerve innervation may be responsible for Pituitary adenylate cyclase-activating polypeptide (Montrer ADCYAP1 Kits ELISA)-regulated hematopoiesis in bone marrow, mainly via PAC1.
PACAP (Montrer ADCYAP1 Kits ELISA)/PAC1 signaling has a role in light regulated food anticipatory activity
PAC1 plays a prominent role in chronic restraint stress response, but less so in the acute restraint stress response.
overexpression of Pac1 rescued the Zac1 (Montrer PLAGL1 Kits ELISA) knockdown neuronal migration phenotype
PAC1 has ligand-independent and dimer-dependent intrinsic/basal activity, conferring cells with anti-apoptotic activities against serum withdrawal, which is involved in the Wnt (Montrer WNT2 Kits ELISA)/beta-catenin (Montrer CTNNB1 Kits ELISA) signal and is associated with the endocytosis of PAC1 dimers.
PACAP (Montrer ADCYAP1 Kits ELISA) and PAC1-R expression increased in cumulus cells isolated at different times after treatment with human chorionic gonadotropin.
These results suggest that Sp1 (Montrer SP1 Kits ELISA) cross-linking might be crucial in negative regulation of PAC1 gene expression due to TG2 (Montrer TGM2 Kits ELISA) in OGD (Montrer FGFR1 Kits ELISA)-induced ER stress.
This study demonistrated that pac1r expression in reactive astrocytes induced by global brain ischemia in mice.
PAC1R mRNA expression in the hippocampus was significantly elevated on day 7 after ischemia induced by bilateral common carotid artery occlusion. .
PAC1R transcript expression exhibited differential responses in NGF (Montrer NGFB Kits ELISA)-OE mice that were tissue (urothelium vs. detrusor) cyclophosphamide-induced-cystitis duration-dependent.
These results suggest that, in fish, PACAP (Montrer VIPR2 Kits ELISA) and PAC1-R may play a role in brain development.
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
PACAP receptor 1
, PACAP type I receptor
, pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
, pituitary adenylate cyclase-activating polypeptide type I receptor
, type I adenylate cyclase activating polypeptide receptor
, PACAP type IA receptor
, adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
, adenylate cyclase activating polypeptide 1 type 1 receptor
, pituitary adenylate cyclase activating polypeptide 1 receptor (1)
, pituitary adenylate cyclase activating polypeptide receptor
, pituitary adenylate cyclase-activating polypeptide type IA receptor
, PAC1 receptor
, adenylate cyclase activating polypeptide 1 receptor 1
, pituitary adenylate cyclase activating polypeptide 1 receptor