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Human Polyclonal BAG4 Primary Antibody pour FACS, WB - ABIN4355089
Endres, Häcker, Brosch, Pfeffer: Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domains. dans Molecular and cellular biology 2003
Show all 4 Pubmed References
Human Polyclonal BAG4 Primary Antibody pour ELISA, WB - ABIN449854
Takada, Chen, Mirtsos, Suzuki, Suzuki, Wakeham, Mak, Yeh: Role of SODD in regulation of tumor necrosis factor responses. dans Molecular and cellular biology 2003
Show all 2 Pubmed References
Human Polyclonal BAG4 Primary Antibody pour ELISA, ICC - ABIN4355093
Gupta, Tahrir, Knezevic, White, Gordon, Cheung, Khalili, Feldman: GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis. dans Journal of cellular biochemistry 2016
Human Polyclonal BAG4 Primary Antibody pour IHC (fro), IHC (p) - ABIN4355096
Aust, Pils, Polterauer, Horvat, Cacsire Castillo-Tong, Pils, Dudek, Schmid, Speiser, Reinthaller, Grimm: Expression of Bcl-2 and the antiapoptotic BAG family proteins in ovarian cancer. dans Applied immunohistochemistry & molecular morphology : AIMM 2013
acid-induced increase in SODD expression and decrease in cell apoptosis may depend on the activation of NOX5 (Montrer NOX5 Anticorps)-S and NF-kappaB1 p50 (Montrer NFKB1 Anticorps) in FLO (Montrer AHCTF1 Anticorps) cells
SGK1.1 regulates gene transcription upon a different set of genes some of which participate in cell survival pathways (BAG-4) and others in intracellular vesicular traffic (Brox).
SODD over-expression might be correlated with the clinical classification, curative effect, and prognosis of ALL cells.
MicroRNA-26a is strongly downregulated in melanoma and induces cell death through repression of silencer of death domains (SODD).
Altered signaling of TNFalpha (Montrer TNF Anticorps)-TNFR1 (Montrer TNFRSF1A Anticorps) and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells.
SODD/BAG-4 is not only a silencer of TNFR1 (Montrer TNFRSF1A Anticorps) but also a modulator of CD95 (Montrer FAS Anticorps) activity, regulating the balance of both death-promoting and -depressing signals
These data confirm that silencer of death domains (SODD) and death receptor 3 (DR3 (Montrer TNFRSF25 Anticorps)) are expressed in a regulated manner during renal transplant rejection, and identify DR3 (Montrer TNFRSF25 Anticorps) as a potential inducible mediator of tubular inflammation and injury.
BAG-4 functions as a negative regulator for apobec-1 (Montrer APOBEC1 Anticorps)-mediated apoB (Montrer APOB Anticorps) mRNA editing
results of analysis of the genome-wide scan data was a 20 cM region at 8p11-23 in which markers had LODs > or =1.0. Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 (Montrer FGFR1 Anticorps) and BAG4.
Vincristine induces Jurkat cell apoptosis by downregulating expression of SODD protein and priming the death receptor pathway.
Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt (Montrer AKT1 Anticorps) signaling to the actin cytoskeleton.
Results suggest that silencer of death domains protein (SODD) is critical for the regulation of tumor necrosis factor (Montrer TNF Anticorps) signaling.
our data do not support the concept of a unique, nonredundant role of SODD for the functions of TNFR1 (Montrer TNFRSF1A Anticorps), Hsp70 (Montrer HSP70 Anticorps), and DR3 (Montrer TNFRSF25 Anticorps).
The proapoptotic proteins Bak (Montrer BAK1 Anticorps) (Bcl-2 (Montrer BCL2 Anticorps) antagonistic killer) and Bax (Montrer BAX Anticorps) (Bcl-2 (Montrer BCL2 Anticorps)-associated X protein) were depleted in livers from TCPOBOP-treated CAR+/+ mice.
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
BCL2-associated athanogene 4
, BAG family molecular chaperone regulator 4
, BAG-family molecular chaperone regulator-4
, bcl-2-associated athanogene 4
, silencer of death domains