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Data show that hRALDH2 is not inhibited by its oxidation product, all-trans-RA, suggesting the absence of a negative feedback regulatory loop. Expression of the Raldh2 gene is known to be regulated by RA itself, suggesting that the main regulation of the hRALDH2 activity level is transcriptional.
Study shows no evidence that genetic variants alter prostate cancer incidence, but show that SNPs in the ALDH1A2 gene affect prostate cancer mortality.
a critical role of ALDH1A2-RAR (Montrer RARA Kits ELISA) signaling in the pathogenesis of head and neck cancer.
High expression of ALDH1A2 and ALDH1B1 (Montrer ALDH1B1 Kits ELISA) mRNA was found to be significantly correlated to worser survival in all NSCLC patients.
the distribution of RALDH1 (Montrer ALDH1A1 Kits ELISA), RALDH2, and RALDH3 (Montrer ALDH1A3 Kits ELISA) in the postnatal eye was determined.
ALDH1A2 is involved in the regulation of cancer stem cell properties in neuroblastoma (Montrer ARHGEF16 Kits ELISA).
Genetic association replicative and exploratory studies identify SNPs in ADA (Montrer ADA Kits ELISA) and MTR (Montrer MTR Kits ELISA) highly associated with isolated Neural tube defects (NTD)and SNP in ARID1A (Montrer ARID1A Kits ELISA) and ALDH1A2 associated with NTDs in whites and African Americans respectively.
At the transcript level, the cisplatin + DEAB-resistant cells showed upregulated mRNA expression levels for ALDH1A2, ALDH1A3 (Montrer ALDH1A3 Kits ELISA) isozymes and CD44 (Montrer CD44 Kits ELISA) indicating the involvement of these markers in conferring chemoresistance
DNA methylation (Montrer HELLS Kits ELISA) at multiple CpG sites is associated with loss of control over alcohol drinking.
Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.
Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of Raldh2 directly.
The novel aldh1a2 reporter line is driven by the complete set of regulatory sequences required for zebrafish development, reports novel sources of RA synthesis, and identifies the source of RA that promotes vertebral ossification.
aldh1a2 participate to a positive loop required for branchial arches development in zebrafish
Aldh1a2 is the primary aldehyde dehydrogenase acting during pancreas development and maternal Aldh1a2 activity persists in aldh1a2(um22) and aldh1a2(i26) mutant embryos.
Studies indicate that raldh2 expression is critical for the formation of wound epithelium and blastema.
these studies identify Notch (Montrer NOTCH1 Kits ELISA) signaling in dendritic cells as a crucial balancer of Th17/iTreg, which depends on the direct regulation of Aldh1a2 (Montrer ALDH1A1 Kits ELISA) transcription in dendritic cells
ALDH2 (Montrer ALDH2 Kits ELISA) mutation displays an inverse correlation of coronary collateral vessel formation in patients.
Data suggest that retinoic acid and GM-CSF (Montrer CSF2 Kits ELISA)-induced retinal dehydrogenase 2 (RALDH2) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (Montrer SP1 Kits ELISA) via the RA receptor/retinoid X receptor (Montrer RXRB Kits ELISA) complex to the Aldh1a2 (Montrer ALDH1A1 Kits ELISA) promoter.
all three proteins (RDH10 (Montrer RDH10 Kits ELISA), RALDH2, and CRABP2 (Montrer CRABP2 Kits ELISA)) appeared to be required for ATRA production induced by activation of PPARgamma (Montrer PPARG Kits ELISA)
Defects in interdigital programmed cell death and digit separation in Hoxa13 (Montrer HOXA13 Kits ELISA) mutant mice may be caused in part by reduced levels of RA signaling stemming from a loss in the direct regulation of Aldh1a2 (Montrer ALDH1A1 Kits ELISA)
Raldh1 (Montrer ALDH1A1 Kits ELISA) and Raldh3 (Montrer ALDH1A3 Kits ELISA) influence enteric nervous system structure and function and heterozygosity for Raldh2 causes ENS defects
ALDH1A2 expression was highest in ALDH(very-br) cells, intermediate in ALDH(dim) cells, and lowest in ALDH(br) cells.
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
rendered Fgfr2IIIb (Montrer FGFR2 Kits ELISA)(-/-) embryos haploinsufficient for the Raldh2 and examined these embryos for the incidence and severity of duodenal atresia
Expression of ALDH1A2 (Montrer ALDH1A1 Kits ELISA), BEX2 (Montrer BEX2 Kits ELISA), EGR2 (Montrer EGR2 Kits ELISA), CCL3 (Montrer CCL3 Kits ELISA) and PLAU (Montrer PLAU Kits ELISA) are upregulated in Toxoplasma gondiisusceptible C57BL/6 mice.
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene.
, aldehyde dehydrogenase 1A2
, aldehyde dehydrogenase family 1 member A2
, aldehyde dehydrogenase family 1, subfamily A2
, retinal dehydrogenase 2
, retinal dehydrogenase, type II
, retinaldehyde-specific dehydrogenase type 2
, retinaldehyde dehydrogenase 2
, alcohol dehydrogenase family 1, subfamily A2
, alcohol dehydrogenase family 1, subfamily A7