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anti-Human DDX6 Anticorps:
anti-Rat (Rattus) DDX6 Anticorps:
anti-Mouse (Murine) DDX6 Anticorps:
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Human Polyclonal DDX6 Primary Antibody pour ICC, IF - ABIN152327
Nonhoff, Ralser, Welzel, Piccini, Balzereit, Yaspo, Lehrach, Krobitsch: Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. dans Molecular biology of the cell 2007
Show all 29 Pubmed References
Human Polyclonal DDX6 Primary Antibody pour ICC, IF - ABIN152328
Sivan, Kedersha, Elroy-Stein: Ribosomal slowdown mediates translational arrest during cellular division. dans Molecular and cellular biology 2007
Show all 16 Pubmed References
Human Monoclonal DDX6 Primary Antibody pour IHC (p), RNAi - ABIN560590
Broytman, Westmark, Gurel, Malter: Rck/p54 interacts with APP mRNA as part of a multi-protein complex and enhances APP mRNA and protein expression in neuronal cell lines. dans Neurobiology of aging 2009
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Human Polyclonal DDX6 Primary Antibody pour ELISA, WB - ABIN251278
Cougot, Babajko, Séraphin: Cytoplasmic foci are sites of mRNA decay in human cells. dans The Journal of cell biology 2004
DDX6 modulates interaction of miR (Montrer MLXIP Anticorps)-122 with the 5' untranslated region of hepatitis C virus RNA.
we demonstrate that joint deletion of two short conserved motifs that bind UNR (Montrer P2RY4 Anticorps) and DDX6 relieves repression of 4E-T (Montrer EIF4ENIF1 Anticorps)-bound mRNA, in part reliant on the 4E-T (Montrer EIF4ENIF1 Anticorps)-DDX6-CNOT1 (Montrer CNOT1 Anticorps) axis.
miRNAs, AGOs, GW182, the CCR4 (Montrer CCR4 Anticorps)-NOT complex, and DDX6/Me31B repress and degrade polyadenylated mRNA targets that are translated via scanning-independent mechanisms in both human and Drosophila melanogaster cells
DDX6 may have a role in radio- and chemoresistance in glioblastoma
Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 (Montrer PHLDB1 Anticorps) and DDX6 in glioma susceptibility.
DDX6 repression complexes are required for P-body assembly.
Protein Interactome Analysis of DDX6
Results indicate that progenitor function is maintained by DDX6 complexes through two distinct pathways that include the degradation of differentiation-inducing transcripts and by promoting the translation of self-renewal and proliferation mRNAs.
CNOT1 (Montrer CNOT1 Anticorps) facilitates recruitment of DDX6 to miRNA-targeted mRNAs, placing DDX6 as a downstream effector in the miRNA silencing pathway.
study discovered multiple susceptibility variants for systemic lupus erythematosus in the 11q23.3 region, including variants in/near PHLDB1 (Montrer PHLDB1 Anticorps) (rs11603023), DDX6 (rs638893) and CXCR5 (Montrer CXCR5 Anticorps) (rs10892301)
Xp54nrb (Montrer NONO Anticorps) transcripts are expressed throughout early developmental stages, specifically in the neural and sensorial territories and Xp54nrb (Montrer NONO Anticorps) could be involved in anterior neural patterning
An oligomerized form of p54 (Montrer ETS1 Anticorps) RNA helicase (Montrer DDX46 Anticorps) represses mRNA translation.
Data show that RNA helicase DDX6 colocalizes with ubiquitin-protein ligase (Montrer UBE2K Anticorps) TRIM32 (Montrer TRIM32 Anticorps) in neural stem cells and neurons and that it increases the activity of microRNA Let-7a.
rck/p54 may play an important role in gametogenesis and early embryogenesis in mammals
rck/p54 protein was ubiquitously expressed in mouse tissues
RCK/ p54 might be a determinant of colorectal cancer proliferation by activating the canonical Wnt (Montrer WNT2 Anticorps) pathway
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
, DEAD box protein 6
, RNA helicase p54
, probable ATP-dependent RNA helicase ddx6
, ATP-dependent RNA helicase p54
, DEAD box-6
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD)
, oncogene RCK
, probable ATP-dependent RNA helicase DDX6
, ATP-dependent RNA helicase ddx6
, D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 6
, DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 6
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6
, oncogene RCK homolog