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The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
Stress-resistant translation of c-Src (Montrer SRC Kits ELISA) mRNA is mediated by eIF2A (Montrer EIF2S1 Kits ELISA).
GHRH (Montrer GHRH Kits ELISA) and GHRH-R (Montrer GHRHR Kits ELISA) loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt (Montrer AKT1 Kits ELISA) and eIF2a (Montrer EIF2S1 Kits ELISA) pathways.
These findings suggest that phosphorylated-eIF2alpha regulates synaptic actions of nicotine in both mice and humans, and that reduced phosphorylated-eIF2alpha may enhance susceptibility to nicotine (and other drugs of abuse) during adolescence.
The results suggest that dephosphorylation of eIF2a (Montrer EIF2S1 Kits ELISA) by GADD34 (Montrer PPP1R15A Kits ELISA) plays an important role in doxorubicin resistance of MCF-7/ADR (Montrer AKR1B1 Kits ELISA) cells.
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (Montrer EIF2S1 Kits ELISA), which is mediated by continual activation of PKR (Montrer PKLR Kits ELISA) and degradation of PP1 (Montrer PPA1 Kits ELISA).
We identified EIF2A (Montrer EIF2S1 Kits ELISA) phosphorylation as a novel early molecular event occurring in response to NAMPT (Montrer NAMPT Kits ELISA) inhibition and mediating protein synthesis arrest.
These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation.
analysis of the ER stress response in immunogenic cell death and the potential value of eIF2alpha phosphorylation as a biomarker for this clinically relevant variant of apoptosis [review]
The data highlight independent interactions of PP1 (Montrer PPA1 Kits ELISA) and eIF2alpha with GADD34 (Montrer PPP1R15A Kits ELISA), demonstrating that GADD34 (Montrer PPP1R15A Kits ELISA) functions as a scaffold both in vitro and in cells
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (Montrer PPP1CA Kits ELISA) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (Montrer ATF4 Kits ELISA) expression. (eIF2a = eukaryotic initiation factor-2alpha (Montrer EIF2S1 Kits ELISA); PPP1CA (Montrer PPP1CA Kits ELISA) = protein phosphatase 1 catalytic subunit alpha; Atf4 (Montrer ATF4 Kits ELISA) = activating transcription factor 4 (Montrer ATF4 Kits ELISA))
ER stress-induced increase in ATF4 (Montrer ATF4 Kits ELISA) and CHOP (Montrer DDIT3 Kits ELISA) expression is initiated by an increase in Atf4 (Montrer ATF4 Kits ELISA) and Chop (Montrer DDIT3 Kits ELISA) mRNA, which is also dependent upon eIF2alpha phosphorylation.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
in mouse skeletal muscle stem cells, general repression of translation, mediated by the phosphorylation of translation initiation factor eIF2alpha at serine 51 (P-eIF2alpha), is required to maintain the quiescent state
Skeletal muscle-specific (Montrer EIF3K Kits ELISA) eukaryotic translation initiation factor 2alpha (Montrer EIF2S1 Kits ELISA) phosphorylation controls amino acid metabolism and fibroblast growth factor 21 (Montrer FGF21 Kits ELISA)-mediated non-cell-autonomous energy metabolism.
PGRN (Montrer GRN Kits ELISA) is a key regulator of insulin (Montrer INS Kits ELISA) resistance and PGRN (Montrer GRN Kits ELISA) may mediate its effects, at least in part, by inducing ER stress via the PERK (Montrer EIF2AK3 Kits ELISA)-eIF2alpha dependent pathway
The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha-ATF4 (Montrer ATF4 Kits ELISA) axis and to develop drugs targeting this important pathway in the remediation of related pathologies.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
, eukaryotic translation initiation factor 2 subunit 1
, eukaryotic translation initiation factor 2 subunit alpha
, Eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, GTP-exchange protein
, eIF-2B GDP-GTP exchange factor subunit alpha
, translation initiation factor eIF-2B subunit alpha