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Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
in mouse skeletal muscle stem cells, general repression of translation, mediated by the phosphorylation of translation initiation factor eIF2alpha at serine 51 (P-eIF2alpha), is required to maintain the quiescent state
Skeletal muscle-specific (Montrer EIF3K Kits ELISA) eukaryotic translation initiation factor 2alpha (Montrer EIF2S1 Kits ELISA) phosphorylation controls amino acid metabolism and fibroblast growth factor 21 (Montrer FGF21 Kits ELISA)-mediated non-cell-autonomous energy metabolism.
These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation.
PGRN (Montrer GRN Kits ELISA) is a key regulator of insulin (Montrer INS Kits ELISA) resistance and PGRN (Montrer GRN Kits ELISA) may mediate its effects, at least in part, by inducing ER stress via the PERK (Montrer EIF2AK3 Kits ELISA)-eIF2alpha dependent pathway
The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha-ATF4 (Montrer ATF4 Kits ELISA) axis and to develop drugs targeting this important pathway in the remediation of related pathologies.
inhibition of eIF2alpha and FAK (Montrer PTK2 Kits ELISA) signaling may play an important role in cigarette smoking-induced lung EC apoptosis and emphysema
eIF2a phosphorylation is required for the normal function of intestinal Paneth cells and mucosal homeostasis.
Hypothalamic eIF2alpha phosphorylation could play a critical role in the onset of anorexia associated with certain diseases.
The pathogenesis of cardiomyopathy in Frederich ataxia (Montrer USP14 Kits ELISA) correlates with the early and persistent eIF2alpha phosphorylation.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
GHRH (Montrer GHRH Kits ELISA) and GHRH-R (Montrer GHRHR Kits ELISA) loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt (Montrer AKT1 Kits ELISA) and eIF2a (Montrer EIF2S1 Kits ELISA) pathways.
These findings suggest that phosphorylated-eIF2alpha regulates synaptic actions of nicotine in both mice and humans, and that reduced phosphorylated-eIF2alpha may enhance susceptibility to nicotine (and other drugs of abuse) during adolescence.
The results suggest that dephosphorylation of eIF2a (Montrer EIF2S1 Kits ELISA) by GADD34 (Montrer PPP1R15A Kits ELISA) plays an important role in doxorubicin resistance of MCF-7/ADR (Montrer AKR1B1 Kits ELISA) cells.
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (Montrer EIF2S1 Kits ELISA), which is mediated by continual activation of PKR (Montrer PKLR Kits ELISA) and degradation of PP1 (Montrer PPA1 Kits ELISA).
We identified EIF2A (Montrer EIF2S1 Kits ELISA) phosphorylation as a novel early molecular event occurring in response to NAMPT (Montrer NAMPT Kits ELISA) inhibition and mediating protein synthesis arrest.
analysis of the ER stress response in immunogenic cell death and the potential value of eIF2alpha phosphorylation as a biomarker for this clinically relevant variant of apoptosis [review]
The data highlight independent interactions of PP1 (Montrer PPA1 Kits ELISA) and eIF2alpha with GADD34 (Montrer PPP1R15A Kits ELISA), demonstrating that GADD34 (Montrer PPP1R15A Kits ELISA) functions as a scaffold both in vitro and in cells
hypusine-eIF5A (Montrer EIF5 Kits ELISA)-facilitated translation elongation promotes arsenite-induced polysome disassembly and stress granule assembly in cells subjected to adverse environmental conditions
There was no statistically significant difference in IFN therapeutic effectiveness among the patients with different genotypes of eIF-2a (Montrer EIF2S1 Kits ELISA)-reg2 (Montrer FLOT1 Kits ELISA).
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, 65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A