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The BRAF/MAP2K1-mut LCH cells had a more immature state than BRAF/MAP2K1-wt LCH cells. Authors also found the BRAFV600E and MAP2K1 mutations were significantly associated with pERK expression.
There are no other biomarkers correlated with treatment responses following MEK1/2 inhibition.
High MEK1 expression is associated with neuroblastoma (Montrer ARHGEF16 Protéines).
mutations in MAP2K1, which are frequently associated with neurological complications and intellectual disability, can be associated with a milder clinical and neurocognitive profile more typical of individuals with Noonan syndrome. Variability of expression may arise from a complex interplay between RAS/MAPK (Montrer MAPK1 Protéines) pathway genotype, epigenetics, medical and obstetric factors, and environmental influences.
High MEK1 expression is associated with infant acute lymphoblastic leukemia.
Data show that combined therapy using HER2 (Montrer ERBB2 Protéines) inhibitor and BRAF (Montrer BRAF Protéines)/MEK inhibitor presented more significant redifferentiation effect on papillary thyroid cancer cells harboring BRAFV600E than BRAF (Montrer BRAF Protéines)/MEK inhibitor alone.
MEK1 is constitutively and mainly phosphorylated at the Thr (Montrer TRH Protéines)-292, Ser (Montrer SIGLEC1 Protéines)-298, Thr (Montrer TRH Protéines)-386, and Thr (Montrer TRH Protéines)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (Montrer TRH Protéines)-292, Ser (Montrer SIGLEC1 Protéines)-298, Thr (Montrer TRH Protéines)-386, and Thr (Montrer TRH Protéines)-388 residues vary widely during activation and deactivation of the MAPK (Montrer MAPK1 Protéines) pathway.
TNFRSF14 (Montrer TNFRSF14 Protéines) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.
There was no statistically significant association between BRAF (Montrer BRAF Protéines) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.
High MEK1 expression is associated with inflammation.
data suggest that, although short-term suppression of Mek1/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential
Cdk5 (Montrer CDK5 Protéines) may play an important role in endoplasmic reticulum stress induced podocyte apoptosis through MEKK1/JNK (Montrer MAPK8 Protéines) pathway in diabetic nephropathy.
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
High MEK1 expression is associated with Melanoma Metastasis.
cartilage-specific inactivation of miR322 in mice linked the loss of miR (Montrer MLXIP Protéines)-322 to decreased MEK1 levels and to increased RAF (Montrer RAF1 Protéines)/MEK (Montrer MDK Protéines)/ERK (Montrer EPHB2 Protéines) pathway activation.
fluid shear stress induces autocrine TGF-beta (Montrer TGFB1 Protéines)/ALK5 (Montrer TGFBR1 Protéines)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.
Lgr4 (Montrer LGR4 Protéines) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) pathways.
FGF2 (Montrer FGF2 Protéines) is an extracellular inducer of COUP-TFII (Montrer NR2F2 Protéines) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (Montrer NR2F2 Protéines) expression prior to the onset of osteogenic differentiation
REDD1 (Montrer DDIT4 Protéines) is required for normal insulin (Montrer INS Protéines)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (Montrer DDIT4 Protéines), and mTOR (Montrer FRAP1 Protéines)
blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (Montrer LEPR Protéines) mice
in FGFR1 (Montrer FGFR1 Protéines) signalling JNK1 (Montrer MAPK8 Protéines) phosphorylation depends on ERK2 (Montrer MAPK1 Protéines)
The data demonstrate that ERK (Montrer MAPK1 Protéines) phosphorylation of UBF prevents DNA bending by its first two HMG (Montrer SSRP1 Protéines) boxes, leading to a cooperative unfolding of the enhancesome
We propose that Erk2 MAP kinase (Montrer MAPK1 Protéines) phosphorylation of Vg1RBP (Montrer IGF2BP3 Protéines) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.
Extracellular signal-regulated kinase (ERK (Montrer MAPK1 Protéines)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.
KSR (Montrer KSR1 Protéines) interacts with a regulatory Raf (Montrer RAF1 Protéines) molecule in cis (Montrer CISH Protéines) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (Montrer RAF1 Protéines) molecule in trans
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Genetic and biochemical evidences not only show that MEK1-MPK6 (Montrer MAPK6 Protéines) cascade, AtRBOHD/F-dependent H2O2 and NIA1-dependent NO are all involved in dark-induced stomatal closure in Arabidopsis, also indicate that MEK1-MPK6 (Montrer MAPK6 Protéines) cascade functions via working downstream of H2O2 and upstream of NO.
Data indicate that MEKK2 (Montrer MAP3K2 Protéines) is required for the mekk1 (Montrer MAP3K1 Protéines), mkk1 mkk2 (Montrer MAP2K2 Protéines), and mpk4 (Montrer MAPK4 Protéines) autoimmune phenotypes.
Data suggest that the MEKK1 (Montrer MAP3K1 Protéines)-MKK1/MKK2 (Montrer MAP2K2 Protéines)-MPK4 (Montrer MAPK4 Protéines) kinase cascade negatively regulates MEKK2 (Montrer MAP3K2 Protéines) and activation of MEKK2 (Montrer MAP3K2 Protéines) triggers SUMM2-mediated immune responses.
miR (Montrer MYLIP Protéines)-1826 plays an important role as tumor suppressor via CTNNB1 (Montrer CTNNB1 Protéines)/MEK1/VEGFC (Montrer VEGFC Protéines) downregulation in bladder cancer.
ETS1 (Montrer ETS1 Protéines) is probably mediating high CIP2A (Montrer KIAA1524 Protéines) expression in human cancers with increased EGFR (Montrer EGFR Protéines)-MEK1/2-ERK (Montrer MAPK1 Protéines) pathway activity
An analysis of the interation of MEKK1 (Montrer MAP3K1 Protéines) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.
This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.
These results suggest that the formation of SUMO-1 (Montrer SUMO1 Protéines) foci is regulated by the MEK-ERK (Montrer MAPK1 Protéines) pathway and may induce apoptosis.
AtMEK1 is a crucial mediator in plant stress signal transduction.
double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (Montrer MAP2K2 Protéines) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (Montrer MAP3K1 Protéines) and mpk4 (Montrer MAPK4 Protéines) mutants
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
ERK activator kinase 1
, MAP kinase kinase 1
, MAP kinase/Erk kinase 1
, MAPK/ERK kinase 1
, MAPKK 1
, dual specificity mitogen-activated protein kinase kinase 1
, mitogen-activated protein kinase kinase 1
, MEK 1
, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
, dual specificity mitogen activated protein kinase kinase 1
, mitogen activated protein kinase kinase 1
, protein kinase, mitogen activated, kinase 1, p45
, MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2)