Aperçu des produits pour MAP2K1 Protéines (MAP2K1)

Full name:
Mitogen-Activated Protein Kinase Kinase 1 Protéines (MAP2K1)
Chez www.anticorps-enligne.fr sont 22 Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Protéines de 9 de différents fournisseurs disponibles. De plus, nous expédions MAP2K1 Anticorps (628) et MAP2K1 Kits (31) et beaucoup plus de produits pour cette protéine. Un total de 721 MAP2K1 produits sont actuellement listés.
Synonymes:
ATMEK1, CFC3, F20B18.180, F20B18_180, MAP kinase/ ERK kinase 1, MAPKK1, MEK, mek-2, MEK1, MEKK1, MITOGEN ACTIVATED PROTEIN KINASE KINASE, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1, MKK1, NMAPKK, Prkmk1, si:ch211-242m18.2, wu:fj56a12, wu:fj61b01, zgc:56557
afficher tous les protéines Gène GeneID UniProt
MAP2K1 170851 Q01986
MAP2K1 5604 Q02750
MAP2K1 26395 P31938

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MAP2K1 Protéines (MAP2K1) par origine

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MAP2K1 Protéines mieux référencés

  1. Mouse (Murine) MAP2K1 Protein expressed in Baculovirus infected Insect Cells - ABIN3216428 : Duesbery, Webb, Leppla, Gordon, Klimpel, Copeland, Ahn, Oskarsson, Fukasawa, Paull, Vande Woude: Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. dans Science (New York, N.Y.) 1998 (PubMed)
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Plus protéines pour MAP2K1 partenaires d'interaction

Human Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. MEK1 is constitutively and mainly phosphorylated at the Thr (Montrer TRH Protéines)-292, Ser (Montrer SIGLEC1 Protéines)-298, Thr (Montrer TRH Protéines)-386, and Thr (Montrer TRH Protéines)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (Montrer TRH Protéines)-292, Ser (Montrer SIGLEC1 Protéines)-298, Thr (Montrer TRH Protéines)-386, and Thr (Montrer TRH Protéines)-388 residues vary widely during activation and deactivation of the MAPK (Montrer MAPK1 Protéines) pathway.

  2. TNFRSF14 (Montrer TNFRSF14 Protéines) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.

  3. There was no statistically significant association between BRAF (Montrer BRAF Protéines) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.

  4. High MEK1 expression is associated with inflammation.

  5. Lgr4 (Montrer LGR4 Protéines) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) pathways.

  6. somatic mutations in MAP2K1 are a common cause of extracranial arteriovenous malformation

  7. MEK1 mutation is associated with central nervous system metastases of non-small cell lung cancer.

  8. The MAP2K1 mutation analysis of three hairy cell leukemia cases, one hairy cell leukemia-variant case, and three splenic marginal zone lymphoma cases revealed negative results.

  9. Data show that mitogen-activated protein kinase (Montrer MAPK1 Protéines) kinases MEK1/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.

  10. the purpose of this paper was to investigate MAPK (Montrer MAPK1 Protéines) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Lgr4 (Montrer LGR4 Protéines) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) pathways.

  2. FGF2 (Montrer FGF2 Protéines) is an extracellular inducer of COUP-TFII (Montrer NR2F2 Protéines) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (Montrer NR2F2 Protéines) expression prior to the onset of osteogenic differentiation

  3. REDD1 (Montrer DDIT4 Protéines) is required for normal insulin (Montrer INS Protéines)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (Montrer DDIT4 Protéines), and mTOR (Montrer FRAP1 Protéines)

  4. blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (Montrer LEPR Protéines) mice

  5. MEK1 and MEK2 (Montrer MAP2K2 Protéines) can substitute for each other but a minimum amount of MEK (Montrer MDK Protéines) is critical for placenta development and embryo survival

  6. Aberrant phosphorylation of AKT (Montrer AKT1 Protéines) and MEK (Montrer MDK Protéines) signalling pathways was identified in cells carrying mutant huntingtin (Montrer HTT Protéines).

  7. An essential function for MEK1 in macrophages in regulating the ERK1/2 and STAT4 (Montrer STAT4 Protéines) pathways in response to TLR4 (Montrer TLR4 Protéines) activation.

  8. Nuclear enrichment of MEK1 physically sequesters peroxisome proliferator-activated receptor gamma (PPARgamma (Montrer PPARG Protéines)), inhibiting adipogenesis and disrupting ERK (Montrer EPHB2 Protéines) signaling.

  9. MEK1 is inhibited by phosphorylation at Thr (Montrer TRH Protéines)-292/286 by Cdk5 (Montrer CDK5 Protéines), ERK (Montrer EPHB2 Protéines), and Cdk1 (Montrer CDK1 Protéines).

  10. The effect of Akt1 (Montrer AKT1 Protéines) and Mek1 on extracellular matrix synthesis was reconciled through the activation of p70 S6-kinase (Montrer PRKACB Protéines).

Xenopus laevis Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. in FGFR1 (Montrer FGFR1 Protéines) signalling JNK1 (Montrer MAPK8 Protéines) phosphorylation depends on ERK2 (Montrer MAPK1 Protéines)

  2. The data demonstrate that ERK (Montrer MAPK1 Protéines) phosphorylation of UBF prevents DNA bending by its first two HMG (Montrer SSRP1 Protéines) boxes, leading to a cooperative unfolding of the enhancesome

  3. We propose that Erk2 MAP kinase (Montrer MAPK1 Protéines) phosphorylation of Vg1RBP (Montrer IGF2BP3 Protéines) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.

Rabbit Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Extracellular signal-regulated kinase (ERK (Montrer MAPK1 Protéines)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.

  2. KSR (Montrer KSR1 Protéines) interacts with a regulatory Raf (Montrer RAF1 Protéines) molecule in cis (Montrer CISH Protéines) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (Montrer RAF1 Protéines) molecule in trans

Pig (Porcine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Data indicate that MEKK2 (Montrer MAP3K2 Protéines) is required for the mekk1 (Montrer MAP3K1 Protéines), mkk1 mkk2 (Montrer MAP2K2 Protéines), and mpk4 (Montrer MAPK4 Protéines) autoimmune phenotypes.

  2. Data suggest that the MEKK1 (Montrer MAP3K1 Protéines)-MKK1/MKK2 (Montrer MAP2K2 Protéines)-MPK4 (Montrer MAPK4 Protéines) kinase cascade negatively regulates MEKK2 (Montrer MAP3K2 Protéines) and activation of MEKK2 (Montrer MAP3K2 Protéines) triggers SUMM2-mediated immune responses.

  3. miR (Montrer MYLIP Protéines)-1826 plays an important role as tumor suppressor via CTNNB1 (Montrer CTNNB1 Protéines)/MEK1/VEGFC (Montrer VEGFC Protéines) downregulation in bladder cancer.

  4. ETS1 (Montrer ETS1 Protéines) is probably mediating high CIP2A (Montrer KIAA1524 Protéines) expression in human cancers with increased EGFR (Montrer EGFR Protéines)-MEK1/2-ERK (Montrer MAPK1 Protéines) pathway activity

  5. An analysis of the interation of MEKK1 (Montrer MAP3K1 Protéines) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.

  6. This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.

  7. These results suggest that the formation of SUMO-1 (Montrer SUMO1 Protéines) foci is regulated by the MEK-ERK (Montrer MAPK1 Protéines) pathway and may induce apoptosis.

  8. AtMEK1 is a crucial mediator in plant stress signal transduction.

  9. double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (Montrer MAP2K2 Protéines) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (Montrer MAP3K1 Protéines) and mpk4 (Montrer MAPK4 Protéines) mutants

  10. Activation of MPK4 (Montrer MAPK4 Protéines) by flg22 is impaired in the mkk1 mkk2 (Montrer MAP2K2 Protéines) double mutants, suggesting that MKK1 and MKK2 (Montrer MAP2K2 Protéines) function together with MPK4 (Montrer MAPK4 Protéines) and MEKK1 (Montrer MAP3K1 Protéines) in a MAP kinase (Montrer MAPK1 Protéines) cascade to negatively regulate innate immune responses in plants.

Profil protéine MAP2K1

Profil protéine

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Alternative names and synonyms associated with MAP2K1

  • mitogen activated protein kinase kinase 1 (Map2k1)
  • mitogen-activated protein kinase kinase 1 (MAP2K1)
  • mitogen-activated protein kinase kinase 1 (Map2k1)
  • mitogen-activated protein kinase kinase 1 (map2k1)
  • mitogen-activated protein kinase kinase 1 (MEK1)
  • ATMEK1 Protéine
  • CFC3 Protéine
  • F20B18.180 Protéine
  • F20B18_180 Protéine
  • MAP kinase/ ERK kinase 1 Protéine
  • MAPKK1 Protéine
  • MEK Protéine
  • mek-2 Protéine
  • MEK1 Protéine
  • MEKK1 Protéine
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE Protéine
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 Protéine
  • MKK1 Protéine
  • NMAPKK Protéine
  • Prkmk1 Protéine
  • si:ch211-242m18.2 Protéine
  • wu:fj56a12 Protéine
  • wu:fj61b01 Protéine
  • zgc:56557 Protéine

Protein level used designations for MAP2K1

ERK activator kinase 1 , MAP kinase kinase 1 , MAP kinase/Erk kinase 1 , MAPK/ERK kinase 1 , MAPKK 1 , dual specificity mitogen-activated protein kinase kinase 1 , mitogen-activated protein kinase kinase 1 , MEK 1 , protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) , dual specificity mitogen activated protein kinase kinase 1 , mitogen activated protein kinase kinase 1 , protein kinase, mitogen activated, kinase 1, p45 , MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2) , MEK1

GENE ID SPECIES
170851 Rattus norvegicus
5604 Homo sapiens
478347 Canis lupus familiaris
26395 Mus musculus
379991 Xenopus laevis
415549 Gallus gallus
533199 Bos taurus
406728 Danio rerio
100009316 Oryctolagus cuniculus
100233191 Sus scrofa
828713 Arabidopsis thaliana
450188 Pan troglodytes
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