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Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition.
Results indicate that TRN1 positively regulates miRNA activity by promoting the association of miRNAs with AGO1 (Montrer EIF2C1 Kits ELISA), and they reveal opposing roles of two importin beta (Montrer KPNB1 Kits ELISA) family proteins in miRNA loading.
Results show that tranportin 1 (AtTRN1) recognizes a broad spectrum of proteins having diverse functions, which will potentially be the cargoes of AtTRN1.
These results suggest that Aqp0a is the primary water channel (Montrer AQP4 Kits ELISA) of the lens and that Aqp0b, though possibly a secondary water channel (Montrer AQP4 Kits ELISA), has an unidentified function in the lens.
the TNPO1-Rab8 (Montrer RAB8A Kits ELISA)-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia.
SIN1 (Montrer MAPKAP1 Kits ELISA) plays an important role in non-small cell lung cancer; SIN1 (Montrer MAPKAP1 Kits ELISA) is a potential biomarker and a promising target in the treatment of NSCLC
This study provides evidence that Sin1 (Montrer MAPKAP1 Kits ELISA), a known element of the mammalian target of rapamycin (Montrer FRAP1 Kits ELISA) complex 2 (mTORC2 (Montrer CRTC2 Kits ELISA)), is required for Interferon-gamma (Montrer IFNG Kits ELISA)-induced phosphorylation and activation of AKT (Montrer AKT1 Kits ELISA) and that such activation mediates downstream regulation of mTORC1 and its effectors.
Together, these results indicate that transportin-1 mediates YB-1 (Montrer YBX1 Kits ELISA) nuclear translocation.
findings suggest that a new player, i.e., O-GlcNAcylation, regulates hnRNP A1 translocation and interaction with Trn1, possibly affecting its function
Intracellular localization of mTORC2 (Montrer CRTC2 Kits ELISA) component, mSin1, contributes to regulation of Akt (Montrer AKT1 Kits ELISA) phosphorylation.
Importins, Impbeta, Kapbeta2, Imp4, Imp5, Imp7, Imp9, and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly.
Results show that Karyopherin-b2 binds to the N-terminal tail of histone H3 (Montrer HIST3H3 Kits ELISA) with high affinity even though H3 lacks a recognizable proline-tyrosine nuclear localization signal (PY-NLS (Montrer ALDH1A2 Kits ELISA)).
FGF2 (Montrer FGF2 Kits ELISA) nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase (Montrer RAN Kits ELISA) in human glioblastoma cells
Akt (Montrer AKT1 Kits ELISA) phosphorylates SIN1 (Montrer MAPKAP1 Kits ELISA) at T86, enhancing mTORC2 (Montrer CRTC2 Kits ELISA) kinase activity, which leads to phosphorylation of Akt (Montrer AKT1 Kits ELISA) S473 by mTORC2 (Montrer CRTC2 Kits ELISA), thereby catalyzing full activation of Akt (Montrer AKT1 Kits ELISA).
Co-immunoprecipitation and affinity-binding studies revealed that Rab23 (Montrer RAB23 Kits ELISA) exists in a complex with Kif17 and importin b2 implying that Kif17 needs to bind to regulatory proteins like Rab23 (Montrer RAB23 Kits ELISA) for its ciliary transport
Association with Tnpo1 is necessary for Oxtr (Montrer OXTR Kits ELISA) nuclear localization. This is required for Oxt (Montrer OXT Kits ELISA)-induced osteoblast differentiation. osteoblast differentiation.
DJ-1 (Montrer PARK7 Kits ELISA) import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.
Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin (Montrer HTT Kits ELISA) protein.
Tnpo1 is involved in a variety of functions in the adult brain, including neurogenesis, cerebrospinal fluid production and sensing, and circadian rhythms.
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.
M9 region interaction protein
, importin 2
, importin beta 2
, importin beta-2
, karyopherin (importin) beta 2
, karyopherin beta-2
, transportin 1
, major intrinsic protein of lens fiber 1