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Results show that mice with the mutated Plcg2 gene were less prone to transformation into MALT lymphomas as a result of elevated Treg numbers, and decrease of pro-inflammatory cytokines.
PLCgamma2 in clear cells plays an essential role in luminal expansion of the epididymis during the prepubertal period in mice
platelet activation through GPVI (Montrer GP6 Kits ELISA) and alphaIIbbeta3 utilizes PLCgamma2 because PLCgamma1 (Montrer PLCG1 Kits ELISA) levels are insufficient to support responsiveness, but that PLCgamma1 (Montrer PLCG1 Kits ELISA) can restore responsiveness if expressed at levels normally achieved by PLCgamma2.
amarogentin prevents platelet activation through the inhibition of PLC (Montrer HSPG2 Kits ELISA) gamma2-PKC (Montrer PKC Kits ELISA) cascade and MAPK (Montrer MAPK1 Kits ELISA) pathway
PLCgamma2 and protein kinase C (Montrer PKC Kits ELISA) are important upstream signals that regulate myelopoiesis through cytokines.
inflammatory osteolysis can be abrogated by treatment with a molecule composed of the tandem SH2 domains of PLCgamma2.
down-regulation of PLCgamma2-beta-catenin (Montrer CTNNB1 Kits ELISA) pathway occurs in mice and humans and leads to myeloid-derived suppressor cells-mediated tumor expansion.
a novel role of the PLCgamma2-IP(3)-Ca(2 (Montrer CA2 Kits ELISA)+) cascade in the LPS (Montrer TLR4 Kits ELISA)-induced innate immune response pathway where release of intracellular Ca(2 (Montrer CA2 Kits ELISA)+) mediates TLR4 (Montrer TLR4 Kits ELISA) trafficking and subsequent activation of IRF3 (Montrer IRF3 Kits ELISA).
VapB (Montrer VAPB Kits ELISA) positively regulates RANKL (Montrer TNFSF11 Kits ELISA)-mediated osteoclastogenesis via PLCgamma2-Ca(2 (Montrer CA2 Kits ELISA)+)-NFAT (Montrer NFATC1 Kits ELISA) signaling
PLCgamma2 deficiency impairs Dectin-2 (Montrer CLEC6A Kits ELISA)-induced NF-kappaB (Montrer NFKB1 Kits ELISA) and MAPK (Montrer MAPK1 Kits ELISA) activation in response to fungal infection
Data show that protein-altering changes are in PLCG2, ABI3 (Montrer ABI3 Kits ELISA), and TREM2 (Montrer TREM2 Kits ELISA) genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease.
Ocular manifestations of phospholipase-Cgamma2-associated antibody deficiency and immune dysregulation show mutations in the PLC (Montrer HSPG2 Kits ELISA)[gamma]2 gene leading to aberrant function of immune cells and overproduction of interleukin-1 [beta] (IL-1 (Montrer IL1A Kits ELISA)[beta]).
R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transmembrane signals emanating from BCR (Montrer BCR Kits ELISA) and converging on PLCgamma2 through Rac (Montrer AKT1 Kits ELISA) in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or to prevent its development in ibrutinib-treated CLL patients.
Data show that phospholipase Cgamma2 (PLCgamma2) is strongly expressed in B cell non-Hodgkin lymphoma and especially in a large subset of Diffuse large B-cell lymphoma (DLBCL).
Characterization of the effect of missense point-mutation at R665W in PLCG2 on signaling mechanisms of ibrutinib resistance in chronic lymphocytic leukemia cells.
amarogentin prevents platelet activation through the inhibition of PLC (Montrer HSPG2 Kits ELISA) gamma2-PKC cascade and MAPK (Montrer MAPK1 Kits ELISA) pathway
PLCG2 missense mutation is a risk factor in the development of steroid sensitive nephrotic syndrome in childhood.
The autoinhibitory C-terminal SH2 domain of phospholipase C (Montrer PLC Kits ELISA)-gamma2 stabilizes B cell receptor signalosome assembly.
The relationship between upstream tyrosine kinase (Montrer TXK Kits ELISA) SYK (Montrer SYK Kits ELISA) and its target, PLCgamma2, is maximally predictive and sufficient to distinguish chronic lymphocytic leukemia from healthy controls.
Single-nucleotide polymorphisms in PLCG2 gene is associated with breast cancer risk after menopausal hormone replacement therapy.
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
, phosphoinositide phospholipase C-gamma-2
, phospholipase C-gamma-2
, phosphoinositide phospholipase C
, phospholipase C-IV
, phosphatidylinositol-specific phospholipase C