NAD(P)H Dehydrogenase, Quinone 1 Protéines (NQO1)

NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. De plus, nous expédions NQO1 Anticorps (211) et NQO1 Kits (19) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NQO1 1728 P15559
NQO1 24314 P05982
NQO1 18104 Q64669
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Showing 10 out of 14 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Humain His tag   50 μg 2 to 3 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
Levure Rat His tag   1 mg 60 to 71 Days
Escherichia coli (E. coli) Humain His tag   1 mg 2 to 3 Days
Escherichia coli (E. coli) Humain S tag,His tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Rat T7 tag,His tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Souris S tag,His tag 100 μg 15 to 18 Days

NQO1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, , ,
Rat (Rattus) ,
Mouse (Murine)

Plus protéines pour NAD(P)H Dehydrogenase, Quinone 1 (NQO1) partenaires d'interaction

Zebrafish NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway.

Human NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. Therefore, the significant prognostic value of NQO1 in predicting outcome of cancer patients might be explained in part due to the functional contribution of NQO1-SIRT2 axis to mitotic stress.

  2. NQO1*2 polymorphism predicts overall survival in MDS patients.

  3. Patients with a high NQO1 expression showed poor recurrence-free survival and overall survival than patients with a low NQO1 expression in squamous cell carcinoma

  4. The flexibility of NQO1 is critical to its function, and it is impaired in cancer. (Review)

  5. NQO1 is Required for beta-Lapachone-Mediated Downregulation of Breast-Cancer Stem-Cell Activity

  6. this study show that NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy

  7. NQO1 rs1800566 is not a significant genetic factor of warfarin dose for Han Chinese atrial fibrillation patients undergoing catheter ablation.

  8. The NQO1 C609T polymorphism is a risk factor for digestive tract cancers, including colorectal cancer and gastric cancer.[meta-analysis]

  9. Knockdown of NQO1 augments ROS and diminishes cell proliferation. Conversely, overexpression of NQO1 attenuates ROS and increases cell proliferation.

  10. In North African population, the functional NQO1 polymorphism was associated with a significantly higher risk of nasopharyngeal carcinoma among smokers and did not affect the risk among nonsmokers.

  11. functional perturbation analyses at cancer-associated P187 and K240 sites of the multifunctional NADP(H):quinone oxidoreductase 1

  12. NQO1 is a FAD-dependent, two-domain multifunctional stress protein acting as a Phase II enzyme, activating cancer pro-drugs and stabilizing p53 and p73a oncosuppressors.tructural protein:protein interaction studies reveal that the cancer-associated polymorphism does not abolish the interaction with p73alpha, indicating that oncosuppressor destabilization largely mirrors the low intracellular stability of p.P187S.

  13. Inflammation, oxidative stress, and higher expression levels of Nrf2 and NQO1 proteins in the airways of women chronically exposed to biomass fuel smoke.

  14. NQO1 directly binds to the oxygen-dependent domain of HIF-1alpha and inhibits the proteasome-mediated degradation of HIF-1alpha by preventing PHDs from interacting with HIF-1alpha.

  15. Our genetic susceptibility study suggests that the NQO1 wild homozygous is likely to be the susceptible genotype. It means that low dose exposure to benzene (concentration under 0.6 mg/m3) can still cause health hazards to workers, and those workers with NQO1 wild homozygous genotypes were more susceptible than others.

  16. Although the NQO1 rs1800566 variant may not have an effect on risk of pre-eclampsia (PE) in Chinese Han women, further studies of other loci are necessary to clarify the exact role of NQO1 in the pathogenesis of PE.

  17. results obtained here support a previously unrecognized molecular link between polycystic ovary syndrome and endometrial cancer involving NQO1.

  18. In human colonic epithelial cells, significant upregulation of NAD(P)H dehydrogenase [quinone] 1 (up to threefold) and thioredoxin reductase 1 (up to twofold) by 10muM sulforaphane (from broccoli), 5muM carnosol (rosemary), and 20muM cinnamaldehyde (cinnamon) was observed.

  19. Hydrogen sulfide attenuates vascular smooth muscle cell calcification in vitro via the KEAP1-NRF2 redox sensing/stress response system by enhancing NQO1 expression.

  20. the NRF2 target NAD(P)H:quinone oxidoreductase 1 (NQO1) was investigated as a readout parameter for NRF2 activity in monocytes of chronic kidney disease patients (n = 63) compared to those of healthy controls.

Mouse (Murine) NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. results highlight the importance of CYB5R3 and NQO1, two NAD(+) producers, for the promotion of health and extended lifespan

  2. Hepatic GNMT protected mice from aristolochic acids induced nephropathy by enhancing CAR/PXR/CYP3A44/3A41 transcriptions and reducing Nrf2/NQO1 transcriptions.

  3. PDLIM2, known as the ubiquitin E3 ligase, participates in NQO1-dependent IkappaB-zeta degradation.

  4. Antioxidative enzyme Nqo1 regulates ICD through DETC maintenance.

  5. It has been shown that genetic ablation of Nrf2 abolishes an adaptive muscle NQO1 activity and catalase induction.

  6. Although the exact role of NQO1 in prostatic hyperplasia remains unclear, the hyperplasia exacerbation due to NQO1 deletion might be independent of type 2 5alpha-reductase and might be related to enhanced androgen receptor affinity due to enhanced HSP90-alpha expression.

  7. Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.

  8. NQO1 and autophagy participate in a protective role in cisplatin injury.

  9. A significant increase was found in Nrf2-ARE activity after partial hepatectomy (PHx). The signal maximum was recorded on the third day after PHx. Significantly more hepatocytes were positive for Nrf2 and HO-1 on the third postoperative day compared with baseline levels. The mRNA expression of HO-1 and NQO1 were significantly increased on day 3.

  10. Miroestrol restored hepatic NQO1 expression in beta-naphthoflavone-treated mice.

  11. previous and present results collectively show that NQO1 is involved in the formation of tight junctions in the small intestine, and that defects in NQO1 enhance C. difficile toxin A-induced acute inflammatory responses, presumably via the loss of epithelial cell tight junctions

  12. NQO1 plays a critical role in protection against energy depletion in acetaminophen-induced liver injury, and is associated with improvement of mitochondrial dysfunction

  13. The present results demonstrate that exacerbated cisplatin-induced nephrotoxicity under the NQO1-knockout condition was accompanied by the reduced expression of MRN complex proteins, ATM, PARP1, and Sirt1.

  14. Taken together, these data suggest that EEEC attenuates oxidative stress by activating Nrf2-mediated HO-1 and inducing NQO-1 via the activation of MAPK signaling pathways.

  15. We defined the basal and butylated hydroxyanisole induced expression patterns of Nqo1, AKR1B8, and Ho-1 in the liver and small intestine of C57BL/6 mice.

  16. The colons of NQO1-KO mice also showed high levels of reactive oxygen species (ROS) and histone deacetylase (HDAC) activity, which are known to affect transcriptional regulation.

  17. induction by humulusol

  18. the induction of cellular NAD(+) levels using beta-lapachone (beta-Lap), whose intracellular target is NQO1, prevents the toxic effects of cisplatin through the regulation of PARP-1 and SIRT1 activity.

  19. Nqo1 expression is protective against renal ischemia/reperfusion injury in mice.

  20. results indicate that AAI can increase its own metabolic activation by inducing NQO1, thereby enhancing its own genotoxic potential.

Pig (Porcine) NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. The obtained data convincingly showed that porcine NADPH-d cells may produce nitric oxide.

  2. Immunoreactivity of eNOS was similar to NADPH-d staining. Clear iNOS immunoreactivity was detected in the luminal epithelium, endometrial stroma and individual endometrial glands.

Cow (Bovine) NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. NQO1 expression was increased in the ruminal papillae of more efficient low residual feed intake (RFI) animals compared to the high RFI animals

Profil protéine NQO1

Profil protéine

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with NQO1

  • NAD(P)H dehydrogenase, quinone 1 (nqo1)
  • NAD(P)H quinone dehydrogenase 1 (NQO1)
  • NAD(P)H dehydrogenase, quinone 1 (Bpet2092)
  • NAD(P)H dehydrogenase, quinone 1 L homeolog (nqo1.L)
  • NAD(P)H quinone dehydrogenase 1 (nqo1)
  • NAD(P)H quinone dehydrogenase 1 (Nqo1)
  • NAD(P)H dehydrogenase, quinone 1 (Nqo1)
  • AV001255 Protéine
  • DHQU Protéine
  • Dia4 Protéine
  • Dtd Protéine
  • NADPH-d Protéine
  • Nmo-1 Protéine
  • Nmo1 Protéine
  • Nmor1 Protéine
  • NMORI Protéine
  • nqo1 Protéine
  • Ox-1 Protéine
  • Ox1 Protéine
  • Qr1 Protéine
  • wu:fb63c10 Protéine
  • zgc:77191 Protéine

Protein level used designations for NQO1

NAD(P)H dehydrogenase [quinone] 1 , NAD(P)H menadione oxidoreductase 1, dioxin-inducible , NAD(P)H dehydrogenase, quinone 1 , DT-diaphorase , DTD , NAD(P)H:quinone oxidoreductase 1 , QR1 , azoreductase , menadione reductase , phylloquinone reductase , quinone reductase 1 , nad(p)h dehydrogenase (quinone) 1 , NAD(P)H:Quinone acceptor oxidoreductase type 1 , NAD(P)H:menadione oxidoreductase 1 , NAD(P)H:quinone oxireductase , diaphorase (NADH/NADPH) (cytochrome b-5 reductase) , diaphorase-4 , dioxin-inducible 1 , Diaphorase (NADH/NADPH) , NAD(P)H:menadione oxidoreductase , NAD(P)H dehydrogenase (quinone) , NAD(P)H menadione oxidoreductase 1, dioxin inducible , diaphorase 4 (NADH/NADPH) , nicotinamide adenine dinucleotide phosphate diaphorase , diaphorase 4 , NAD(P)H: quinone oxidoreductase 1

322506 Danio rerio
468012 Pan troglodytes
549222 Xenopus (Silurana) tropicalis
705635 Macaca mulatta
769737 Gallus gallus
4606922 Azoarcus sp. BH72
5818094 Bordetella petrii DSM 12804
100049751 Xenopus laevis
100172039 Pongo abelii
100528193 Ictalurus punctatus
1728 Homo sapiens
610935 Canis lupus familiaris
24314 Rattus norvegicus
18104 Mus musculus
100286873 Sus scrofa
519632 Bos taurus
100135582 Cavia porcellus
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