Vitamin K Epoxide Reductase Complex, Subunit 1 Protéines (VKORC1)

Vitamin K is essential for blood clotting but must be enzymatically activated. De plus, nous expédions VKORC1 Anticorps (28) et VKORC1 Kits (14) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
VKORC1 79001 Q9BQB6
VKORC1 27973 Q9CRC0
VKORC1 309004 Q6TEK4
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,493.38
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
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Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Humain Inconjugué   5 applications 1 to 2 Days
$318.85
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VKORC1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, ,
Mouse (Murine)
Rat (Rattus)

Plus protéines pour Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) partenaires d'interaction

Human Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

  1. Of the 41 patients included in the analysis, age, VKORC1, CYP2C9*2/*3 and CYP3A4*1B were statistically significantly associated with dose requirement.

  2. No association between the 9041 G/A and 3673 G/A polymorphisms of the VKORC1 gene and the development of secondary postmenopausal osteoporotic fractures in Turkish patient group.

  3. The presence of mutations in VKORC1 or CYP2C9 is associated with increased risk of bleeding in patients with BCS on warfarin.

  4. The presence of VKORC1 (rs9923231 and rs9934438) allelic variants in the family members suffering from idiopathic pulmonary fibrosis (IPF) indicate a previously unsuspected link between these variants and IPF.

  5. VKROC1 was significantly down-regulated in hepatic tumors and showed prolonged activated partial prothrombin time (APTT). In vivo investigations further showed that VKORC1 expression was promoted by p-mTOR and repressed by p-ERK in both hepatoma and hepatocytes.

  6. VKORC1 rs9923231 determines warfarin dose for Han Chinese atrial fibrillation patients undergoing catheter ablation.

  7. The multivariate regression model was produced, R(2) = 0.05% for age (p = 0.04), R(2) = 6% for VKORC1 (p = 0.03), the model for estimating warfarin dose R(2) = 17% (p > 0.05).

  8. These preliminary results strongly support the use of VKORC1 (-1639G>A) rs9923231 polymorphism for genetically guided initial warfarin dosing in South Indian patients with heart valve replacements.

  9. individuals with polymorphism of CYP2C9 and VKORC1, either alone or combined, are more susceptible to experience bleeding episodes as adverse effect in comparison to individuals having no polymorphism. Similarly, patients having wild (*1/*1) CYP2C9 or VKORC1 GG haplotype may need higher dose of warfarin to maintain INR in therapeutic range.

  10. we have established KO HEK 293T cell lines that express either endogenously VKORC1 or VKORC1L1, and found that VKORC1 is more sensitive to OACs than VKORC1L1, whereas rodenticides apparently inhibit both VKOR enzymes equally

  11. the VKORC1 -1639G>A polymorphism is not a risk factor for postmenopausal osteoporosis

  12. In this study, we showed that patients with VKORC1-1639GA and CYP2C9*1/*1 alleles have lower sensitivity for warfarin than those with VKORC1-1639AA and CYP2C9*1/*1 alleles.

  13. VKORC1-1639A variant allele influenced warfarin daily maintenance dosage among our small, likely admixed Black patient population.

  14. Polymorphism in the promoter region of VKORC1 is effective in warfarin medication.

  15. The plasma S-warfarin (Cp(S)) time courses following the genotype-based dosing algorithms simulated using the PPK estimates showed African Americans with CYP2C9*1/*1 and any of the VKORC1 genotypes would have an average Cp(S) at steady state 1.5-1.8 times higher than in Asians and whites.

  16. The final regression models for White and Black patients (Fig. 1) included age, weight, prosthetic valves, amiodarone use, CYP2C9*3, and VKORC1 3673 G>A genotypes as covariates, whereas possession of CYP2C9*2 and simvastatin use were retained in the final model for White, but not Black patients.

  17. No relationship between VKORC1 variants and clinical outcomes in elderly patients treated with vitamin K antagonists.

  18. Until the age of 19, weight has a far greater effect on Vitamin K antagonist dosing variation than VKORC1 and CYP2C9 polymorphisms. During the age of 20-40years, VKORC1 and CYP2C9 polymorphisms play a significant role.

  19. The VKORC1: c.-1639 G>A polymorphism is associated with aneurysms of the ascending aorta.

  20. 1639G4A polymorphism of the vitamin K epoxide reductase complex subunit 1 gene (VKORC1) is likely to be a new risk factor of Retinal Vascular Occlusion.

Mouse (Murine) Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

  1. The presence of two of the most commonly found amino acid substitutions Leu128Ser and Tyr139Cys associated with house mouse resistance to anticoagulant rodenticides was confirmed. The occurrence of two such mutations is indicative of the occurrence of resistance to anticoagulant rodenticides in house mice in the Eastern region of the island of Ireland.

  2. quantified mRNA levels for VKORC1, VKORC1L1, GGCX, and NQO1 and measured VKOR enzymatic activities in 29 different tissues

  3. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1.

  4. The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.

  5. The three most frequently found sequence variants are associated with a substantial loss of rodenticide efficacy of first-generation anticoagulants, as well as the second-generation compound bromadiolone and most probably also difenacoum.

  6. role in vitamin K-dependent gamma-glutamyl carboxylation; the knockout mice die within 20 days after birth due to intracerebral haemorrhage

  7. molecular cloning [VKORC1]

  8. The genetic basis for resistance to anticoagulants lies in mutations in Vkorc1.

  9. An analysis of novel mutations show that the VKORC1 gene is the main target for spontaneous mutations conferring warfarin resistance.

  10. Each VKORC1 T-allele present in patients from the Rotterdam anticoagulation therapy study is shown to decrease the required acenocoumarol dosage by 5.1 mg/week.

Profil protéine VKORC1

Profil protéine

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.

Gene names and symbols associated with VKORC1

  • vitamin K epoxide reductase complex, subunit 1 (VKORC1)
  • vitamin K epoxide reductase complex subunit 1 (vkorc1)
  • vitamin K epoxide reductase complex, subunit 1 (vkorc1)
  • vitamin K epoxide reductase complex subunit 1 (VKORC1)
  • Vitamin-K epoxide reductase (Vkor)
  • vitamin K epoxide reductase complex, subunit 1 (Vkorc1)
  • BP1071 Protéine
  • CG33544 Protéine
  • D7Wsu86e Protéine
  • Dmel\\CG33544 Protéine
  • EDTP308 Protéine
  • HDC06808 Protéine
  • IMAGE3455200 Protéine
  • MGC89620 Protéine
  • MST134 Protéine
  • MST576 Protéine
  • VKCFD2 Protéine
  • VKOR Protéine
  • VKORC1 Protéine

Protein level used designations for VKORC1

phylloquinone epoxide reductase , vitamin K1 epoxide reductase (warfarin-sensitive) , vitamin K epoxide reductase complex, subunit 1 , CG33544-PA , Vkor-PA , vitamin K dependent clotting factors deficiency 2 , vitamin K epoxide reductase complex subunit 1 , vitamin K1 2,3-epoxide reductase subunit 1 , Warfarin resistance

GENE ID SPECIES
404205 Gallus gallus
446034 Takifugu rubripes
448775 Xenopus (Silurana) tropicalis
479775 Canis lupus familiaris
3346188 Drosophila melanogaster
79001 Homo sapiens
27973 Mus musculus
309004 Rattus norvegicus
445422 Bos taurus
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