(Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009].
Atsriku, Hoffmann, Moghaddam, Kumar, Surapaneni: "In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism." dans: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 45, Issue 6, pp. 465-80, (2015) (PubMed).
Pseudonymes pour AKR1B1 Protéines
aldo-keto reductase family 1 member B (AKR1B1) Protéines aldo-keto reductase family 1 member B (Akr1b1) Protéines aldo-keto reductase family 1, member B1 (aldose reductase) (AKR1B1) Protéines aldo-keto reductase family 1, member B1 (aldose reductase) S homeolog (akr1b1.S) Protéines aldo-keto reductase family 1, member B1 (aldose reductase) (akr1b1) Protéines ADR Protéines Akr1b3 Protéines Akr1b4 Protéines akr1b7 Protéines ALDR1 Protéines Aldr1 Protéines ALDRED Protéines Alr Protéines ALR-P-I Protéines ALR2 Protéines AR Protéines RATALDRED Protéines zgc:86611 Protéines