ISG15 anticorps (AA 2-157) (FITC)

N° du produit ABIN1046252

L’anticorps Lapin Polyclonal anti-ISG15 a été validé pour WB et ELISA. Il convient pour détecter ISG15 dans des échantillons de Humain.

Aperçu rapide pour ISG15 anticorps (AA 2-157) (FITC) (ABIN1046252)

Antigène: ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ISG15 est conjugé à/à la FITC

Application: Western Blotting (WB), ELISA

Détail du produit anti-ISG15 anticorps (FITC)

Épitope: AA 2-157

Fonction: ISG15 Antibody, FITC conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Ubiquitin-like protein ISG15 protein (2-157AA)

Isotype: IgG

Information d'application

Indications d'application: Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze and thaw cycles. Product is photosensitive and should be protected from light.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ISG15

Antigène: ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

Autre désignation: ISG15

Sujet:

Background: Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy

Aliases: G1P2 antibody, hUCRP antibody, IFI 15 antibody, IFI15 antibody, Interferon alpha inducible protein antibody, Interferon induced protein 15 antibody, Interferon induced protein IFI-15K antibody, Interferon stimulated protein 15 kDa antibody, Interferon, alpha-inducible protein (clone IFI-15K) antibody, Interferon-induced 15 kDa protein antibody, Interferon-induced 17 kDa protein antibody, Interferon-induced 17- kDa/15- kDa protein antibody, IP17 antibody, ISG 15 antibody, ISG15 antibody, ISG15 ubiquitin like modifier antibody, ISG15_HUMAN antibody, Ubiquitin cross-reactive protein antibody, Ubiquitin-like protein ISG15 antibody, UCRP antibody

UniProt: P05161