IL13 Receptor alpha 1 anticorps (Extracellular Domain)

N° du produit ABIN108718

Détail du produit anti-IL13 Receptor alpha 1 anticorps

Antigène: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Épitope: Extracellular Domain

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL13 Receptor alpha 1 est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Antagonist (Anta), Cell-ELISA (cELISA)

Specificité: GM1E7 recognises IL-13Ralpha1 transiently expressed on the cell surface of transfected BOSC cells as well as the native protein on monocytes (Myrtek et al., 2004).

Purification: Protein G

Immunogène: genetic immunisation with cDNA encoding human IL13-Ralpha1 (extracellular domain)

Clone: GM-1E7

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C

Stockage commentaire: short term: 2 °C - 8 °C, long term: -20 °C

Détails sur IL13 Receptor alpha 1

Antigène: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Autre désignation: IL13Ra1 (IL13RA1 Produits)

Synonymes: anticorps CD213A2, anticorps CT19, anticorps IL-13R, anticorps IL13BP, anticorps CD213A1, anticorps IL-13Ra, anticorps NR4, anticorps AI882074, anticorps CD213a1, anticorps IL-13r[a], anticorps Il13ra, anticorps IL13RA1, anticorps il-13ra1, anticorps si:ch211-150g2.2, anticorps interleukin 13 receptor subunit alpha 2, anticorps interleukin 13 receptor subunit alpha 1, anticorps interleukin 13 receptor, alpha 1, anticorps interleukin 13 receptor, alpha 1-like, anticorps IL13RA2, anticorps IL13RA1, anticorps Il13ra1, anticorps il13ra1, anticorps LOC100360218

Sujet: Interleukin 13 (IL-13) is a T cell derived cytokine involved in the regulation of inflammatory and im-mune responses. IL-13Rα1 together with IL-4Rα forms a functional receptor for both IL-4 and IL-13, which is why these two cytokines share many of their biological activities. The receptor is found on human B cells, monocytes and endothelial cells. However, no functional receptor is expressed on T cells, which explains why IL-13, in contrast to IL-4, fails to induce TH2-cell differentiation.

UniProt: P78552

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response