KEAP1 anticorps (AA 380-624)

N° du produit ABIN1098137

L’anticorps Souris Monoclonal anti-KEAP1 a été validé pour ELISA, ICC et FACS. Il convient pour détecter KEAP1 dans des échantillons de Humain et Souris. Il y a 2+ publications disponibles.

Aperçu rapide pour KEAP1 anticorps (AA 380-624) (ABIN1098137)

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KEAP1 est non-conjugé

Application: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 1F10B6

Détail du produit anti-KEAP1 anticorps

Épitope: AA 380-624

Fonction: KEAP1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human KEAP1 (AA: 380-624) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-KEAP1 (ABIN1098137)

Kim, You, Lee, Ahn, Seong, Hwang: "Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation." dans: Cellular signalling, Vol. 22, Issue 11, pp. 1645-54, (2010) (PubMed).

Zhang, Singh, Yegnasubramanian, Esopi, Kombairaju, Bodas, Wu, Bova, Biswal: "Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth." dans: Molecular cancer therapeutics, Vol. 9, Issue 2, pp. 336-46, (2010) (PubMed).

Détails sur KEAP1

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Autre désignation: KEAP1

Sujet: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Poids moléculaire: 69.7 kDa

ID gène: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location