KEAP1 anticorps (AA 380-624)

N° du produit ABIN1098141

Cet anticorps anti-KEAP1 est un anticorps Souris Monoclonal détectant KEAP1 dans ELISA, IHC et FACS. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour KEAP1 anticorps (AA 380-624) (ABIN1098141)

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KEAP1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 7G4B10

Détail du produit anti-KEAP1 anticorps

Épitope: AA 380-624

Fonction: KEAP1 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human KEAP1 (AA: 380-624 ) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-KEAP1 (ABIN1098141)

Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: "Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome." dans: Epigenetics, Vol. 6, Issue 3, pp. 317-25, (2011) (PubMed).

Niture, Jaiswal: "INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis." dans: Cell death and differentiation, Vol. 18, Issue 3, pp. 439-51, (2011) (PubMed).

Détails sur KEAP1

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Autre désignation: KEAP1

Sujet: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Poids moléculaire: 69.7 kDa

ID gène: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location