ACLY anticorps (AA 306-502)
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- Antigène Voir toutes ACLY Anticorps
- ACLY (ATP Citrate Lyase (ACLY))
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Épitope
- AA 306-502
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Reactivité
- Humain, Souris, Rat, Singe
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ACLY est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Purification
- purified
- Immunogène
- Purified recombinant fragment of human ACLY (AA: 306-502 ) expressed in E. coli.
- Clone
- 5F8D11
- Isotype
- IgG1
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:50, FCM: 1:200 - 1:400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells." dans: The Journal of biological chemistry, Vol. 285, Issue 42, pp. 32606-15, (2010) (PubMed).
: "Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas." dans: International journal of cancer. Journal international du cancer, Vol. 126, Issue 10, pp. 2282-95, (2010) (PubMed).
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ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells." dans: The Journal of biological chemistry, Vol. 285, Issue 42, pp. 32606-15, (2010) (PubMed).
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- Antigène
- ACLY (ATP Citrate Lyase (ACLY))
- Autre désignation
- ACLY (ACLY Produits)
- Synonymes
- anticorps ACLY, anticorps DDBDRAFT_0205389, anticorps DDBDRAFT_0235360, anticorps DDB_0205389, anticorps DDB_0235360, anticorps ACL, anticorps BcDNA:LD21334, anticorps CG8322, anticorps DmATPCL, anticorps Dmel\\CG8322, anticorps anon-WO0140519.179, anticorps dATPCL, anticorps l(2)01466, anticorps l(2)k09217, anticorps n(2)k09217, anticorps ATPCL, anticorps CLATP, anticorps A730098H14Rik, anticorps AW538652, anticorps Clatp, anticorps acly, anticorps cb722, anticorps zgc:92008, anticorps ATP citrate lyase, anticorps ATP citrate lyase S homeolog, anticorps ATP-citrate synthase, anticorps citrate synthase, mitochondrial, anticorps atp-citrate synthase, anticorps ATP citrate lyase a, anticorps ACLY, anticorps acly.S, anticorps LOC587157, anticorps acly, anticorps ATPCL, anticorps LOC5564509, anticorps CpipJ_CPIJ010291, anticorps Bm1_26245, anticorps ACL, anticorps Acly, anticorps aclya
- Sujet
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Description: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. , , ,
Aliases: ACL, ATPCL, CLATP
- Poids moléculaire
- 125 kDa
- ID gène
- 47
- HGNC
- 47
- Pathways
- L'effet Warburg
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