beta Amyloid anticorps (C-Term)

N° du produit ABIN1105357

Cet anticorps Souris Monoclonal détecte spécifiquement beta Amyloid dans WB, EIA et ELISA (Detection). Il présente une réactivité avec des échantillons de Humain, Souris, Rat et Primate.

Aperçu rapide pour beta Amyloid anticorps (C-Term) (ABIN1105357)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivité: Humain, Souris, Rat, Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Amyloid est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), ELISA (Detection)

Clone: CA9 10C11

Détail du produit anti-beta Amyloid anticorps

Épitope: C-Term

Séquence: MVGGVVIA

Specificité: This antibody specifically recognizes the C-terminal sequence of beta amyloid peptide 42 and full length beta amyloid peptide 42. The antibody does not cross react with beta amyloid peptide 40 in dot blotting and ELISA. Cross-reactivity to beta amyloid peptide 43 is less than 1 % in ELISA.

Réactivité croisée (Details): Species reactivity (tested):Human, Primates, Mouse, Rat.

Purification: Protein G affinity purified

Immunogène: KLH conjugated to a short peptide corresponding to the C-terminal sequence of beta amyloid peptide 42

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with Double distillated water is recommended and to adjust the final concentration to 1.0 mg/mL.

Buffer: 0.01 M PBS pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: Amyloid beta

Sujet: Amyloid beta peptide 42 (Aβ42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Aβ42 and Aβ40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aβ42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aβ42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aβ42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of Aβ42 oligomer is the cause of the disease.

ID gène: 351

Pathways: Inflammasome