beta Amyloid anticorps (N-Term)

N° du produit ABIN1105359

Cet anticorps anti-beta Amyloid est un anticorps Souris Monoclonal détectant beta Amyloid dans WB et EIA. Adapté pour Humain.

Aperçu rapide pour beta Amyloid anticorps (N-Term) (ABIN1105359)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Amyloid est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: NT 5B8

Détail du produit anti-beta Amyloid anticorps

Épitope: N-Term

Séquence: DAEFRHDS

Specificité: This antibody recognizes the N-terminal sequence of human beta amyloid peptide 40 and peptide 42.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein G affinity purified

Immunogène: Human beta amyloid peptide 1-42

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Double distillated water is recommended and to adjust the final concentration to 1.00 mg/mL.

Buffer: 0.01 M PBS pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: Amyloid beta

Sujet: Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

ID gène: 351

Pathways: Inflammasome