beta Amyloid anticorps (N-Term)

N° du produit ABIN1105360

Cet anticorps Souris Monoclonal détecte spécifiquement beta Amyloid dans WB et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour beta Amyloid anticorps (N-Term) (ABIN1105360)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Amyloid est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2C8

Détail du produit anti-beta Amyloid anticorps

Épitope: AA 1-16, N-Term

Réactivité croisée (Details): Species reactivity (tested):Human, weakly with mouse brain

Purification: Protein-A Sepharose

Immunogène: Synthetic amyloid beta peptide corresponding to amino acids 1-16 of human amyloid beta

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2, without preservatives

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: Amyloid beta

Sujet: Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques is a 39-42 amino acid peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial early-onset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: ß-secretase and gamma-secretase. Recent study suggested that a transmembrane aspartic protease, termed beta-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase. This antibody recognizes N-terminal of Aß 40 and Aß 42 specifically.Synonyms: Amyloid beta peptide

Pathways: Inflammasome