beta Amyloid anticorps (N-Term)

N° du produit ABIN1105360

Cet anticorps Souris Monoclonal détecte spécifiquement beta Amyloid dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour beta Amyloid anticorps (N-Term) (ABIN1105360)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Amyloid est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2C8

Détail du produit anti-beta Amyloid anticorps

Épitope: AA 1-16, N-Term

Réactivité croisée (Details): Species reactivity (tested):Human, weakly with mouse brain

Purification: Protein-A Sepharose

Immunogène: Synthetic amyloid beta peptide corresponding to amino acids 1-16 of human amyloid beta

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2, without preservatives

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: Amyloid beta

Sujet: Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques is a 39-42 amino acid peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial early-onset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: ß-secretase and gamma-secretase. Recent study suggested that a transmembrane aspartic protease, termed beta-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase. This antibody recognizes N-terminal of Aß 40 and Aß 42 specifically.Synonyms: Amyloid beta peptide

Pathways: Inflammasome