AOC3 anticorps
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- Antigène Voir toutes AOC3 Anticorps
- AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))
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Reactivité
- Humain, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp AOC3 est non-conjugé
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Application
- Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
- Specificité
- This antibody detects Vascular Adhesion Protein-1 (VAP-1).
- Réactivité croisée (Details)
- Species reactivity (tested):Human, rat
- Purification
- Protein G
- Immunogène
- Purified vessels from human peripheral lymph nodes (ref 1)
- Clone
- 174-5
- Isotype
- IgG1
- Top Product
- Discover our top product AOC3 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.1 % bovine serum albumin
- Stock
- 4 °C
- Stockage commentaire
- Store at 2 - 8 °C.
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- Antigène
- AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))
- Autre désignation
- AOC3 / VAP1 (AOC3 Produits)
- Synonymes
- anticorps HPAO, anticorps SSAO, anticorps VAP-1, anticorps VAP1, anticorps aoc2, anticorps BOLAO, anticorps amine oxidase, copper containing 3, anticorps amine oxidase, copper containing 3 L homeolog, anticorps AOC3, anticorps aoc3.L, anticorps Aoc3
- Sujet
- Vascular Adhesion Protein-1 (VAP-1) is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It contains a short N-terminal cytoplasmic tail, a single membrane-spanning domain and a large extracellular part. A soluble form of VAP-1 (sVAP-1) has been described, which presumably results from the proteolytic cleavage of membrane-bound VAP-1. Structurally VAP-1 belongs to enzymes called semicarbamizide-sensitive amine oxidases, which contain copper as a cofactor. These enzymes deaminate primary amines in a reaction producing hydrogen peroxide, aldehyde, and ammonia. VAP-1 is present in endothelial cells, smooth muscle cells, adipocytes, and in follicular dendritic cells. In endothelial cells the majority of VAP-1 is stored within intracellular granules and translocated to the surface upon inflammation where it regulates leukocyte tissue infiltration. Furthermore, the end-products formed by VAP-1 can also regulate leukocyte migration by signaling effects, have insulin-like effects in energy metabolism, and can cause vascular damage by direct cytotoxicity. Elevated sVAP-1serum levels have been described in several inflammatory diseases as well as colorectal cancer. Moreover, diminished insulin secretion appears to increase the concentration of soluble VAP-1 in plasma. Therefore, VAP-1 might be an interesting diagnostic marker as well therapeutic target for modulating inflammation.Synonyms: Copper amine oxidase, HPAO, Membrane primary amine oxidase, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1
- ID gène
- 8639
- NCBI Accession
- NP_003725
- UniProt
- Q16853
- Pathways
- Feeding Behaviour
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