C1QA anticorps (FITC)
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- Antigène Voir toutes C1QA Anticorps
- C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp C1QA est conjugé à/à la FITC
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Functional Studies (Func)
- Specificité
- The monoclonal antibody JL-1 recognizes the collagen-like region (CLR) of mouse C1q.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, mouse, rat
- Immunogène
- Purified mouse C1q
- Clone
- JL-1
- Isotype
- IgG2b
- Top Product
- Discover our top product C1QA Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.02 % sodium azide, 1 % bovine serum albumin
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2 - 8 °C.
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- Antigène
- C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))
- Autre désignation
- C1q A Subunit (C1QA Produits)
- Synonymes
- anticorps zgc:109903, anticorps C1QA, anticorps AI255395, anticorps C1q, anticorps complement C1q A chain, anticorps complement component 1, q subcomponent, A chain, anticorps complement component 1, q subcomponent, alpha polypeptide, anticorps C1QA, anticorps c1qa, anticorps C1qa
- Sujet
- C1q is a 459 kDa molecule consisting of three individual polypeptide chains. The antibody has been generated by immunization of C1q-/- C57BL/6 mice with purified mouse C1q. C1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can also recognize molecular patterns associated with pathogens and it can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE).Synonyms: Complement 1q, Complement C1q, Complement C1q subcomponent subunit A
- ID gène
- 712
- NCBI Accession
- NP_057075
- UniProt
- P02745
- Pathways
- Système du Complément
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